Kawada Manabu, Momose Isao, Someno Tetsuya, Tsujiuchi Goh, Ikeda Daishiro
Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, Shizuoka, Japan.
J Antibiot (Tokyo). 2009 May;62(5):243-6. doi: 10.1038/ja.2009.20. Epub 2009 Mar 13.
The growth and metastasis of prostate cancer are regulated by prostate stroma through the tumor-stromal cell interactions. Small molecules that modulate the tumor-stromal cell interactions will be new anticancer drugs. In the course of our screening of the modulators, we isolated two new atpenins, NBRI23477 A (4) and B (5), from the fermentation broth of Penicillium atramentosum PF1420. Compounds 4 and 5 as well as atpenin A4 (1), A5 (2) and B (3) inhibited the growth of human prostate cancer DU-145 cells in the coculture with human prostate stromal cells more strongly than that of DU-145 cells alone.
前列腺癌的生长和转移受前列腺基质通过肿瘤-基质细胞相互作用的调节。调节肿瘤-基质细胞相互作用的小分子将成为新型抗癌药物。在我们对调节剂的筛选过程中，我们从墨绿青霉PF1420的发酵液中分离出两种新的atpenin，NBRI23477 A（4）和B（5）。化合物4和5以及atpenin A4（1）、A5（2）和B（3）在与人类前列腺基质细胞共培养时对人类前列腺癌DU-145细胞生长的抑制作用比单独培养DU-145细胞时更强。
