卡波沙霉素，一种由深海菌株链霉菌NTK 937产生的苯并恶唑家族新型抗生素。
Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937.
作者信息
Hohmann Claudia, Schneider Kathrin, Bruntner Christina, Irran Elisabeth, Nicholson Graeme, Bull Alan T, Jones Amanda L, Brown Roselyn, Stach James E M, Goodfellow Michael, Beil Winfried, Krämer Marco, Imhoff Johannes F, Süssmuth Roderich D, Fiedler Hans-Peter
机构信息
Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
出版信息
J Antibiot (Tokyo). 2009 Feb;62(2):99-104. doi: 10.1038/ja.2008.24. Epub 2009 Jan 23.
Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.
卡波沙霉素是一种新型苯并恶唑抗生素，通过高效液相色谱-二极管阵列筛选法在海洋菌株链霉菌NTK 937的提取物中检测到，该菌株从加那利海盆采集的深海沉积物中分离得到。卡波沙霉素的结构通过质谱、核磁共振实验和X射线分析确定。它对革兰氏阳性菌、选定的人类肿瘤细胞系和磷酸二酯酶显示出抑制活性。
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