Clouse R E, Staiano A
Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri 63110.
Am J Physiol. 1991 Oct;261(4 Pt 1):G677-84. doi: 10.1152/ajpgi.1991.261.4.G677.
Topographic plots constructed from conventional esophageal manometric waves were examined in 12 healthy volunteers to better understand spatial relationships of peristaltic contractions. Typical postdeglutitive waves were spatially interconnected using a computerized gridding and plotting system. Contour plots of the resultant peristaltic contraction revealed a consistent separation of a proximal pressure segment from the prominent distal contraction at 21.7 +/- 1.3% of the esophageal length. A second trough in the contraction sequence was found in 11 (91.7%) of the subjects at 64.0 +/- 2.7% of esophageal length separating the distal (smooth muscle) esophagus into two contraction segments. Similar topographic studies were also performed in eight symptomatic patients with frequent double-peaked waves. Poor alignment of the two distal contraction segments was observed in six (75%) of the eight patients. These topographic plots demonstrate previously unrecognized wave relationships and suggest that two neuromuscular contraction units can be detected in the distal smooth muscle esophagus. This technique should be useful in understanding altered relationships of these units under differing physiological conditions or with disease.
对12名健康志愿者构建的传统食管测压波地形图进行了检查，以更好地理解蠕动收缩的空间关系。使用计算机网格化和绘图系统对典型的吞咽后波进行空间连接。所得蠕动收缩的等高线图显示，在食管长度的21.7±1.3%处，近端压力段与明显的远端收缩之间存在一致的分离。在11名（91.7%）受试者中，在食管长度的64.0±2.7%处发现收缩序列中的第二个波谷，将远端（平滑肌）食管分为两个收缩段。还对8名有频繁双峰波症状的患者进行了类似的地形学研究。在8名患者中的6名（75%）观察到两个远端收缩段的排列不佳。这些地形图展示了以前未被认识到的波关系，并表明在远端平滑肌食管中可以检测到两个神经肌肉收缩单元。这项技术在理解不同生理条件下或疾病状态下这些单元的改变关系方面应该是有用的。
