Hoţoleanui Cristina, Jurj Cristina
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca Cluj-Napoca Hospital County, Medical Clinic no. 2, Romania.
Rom J Intern Med. 2008;46(2):119-23.
Chronic venous insufficiency (CVI) represents an important medical and social problem with a significant impact on the quality of life. Although the mechanisms of occurrence and development of chronic venous insufficiency became better understood in the last decades, the contribution of genetic risk factors is not precisely established. Many factors are involved in the etiopathogenesis of CVI, such as age, sex, heredity, sedentary life style. The impact of genetic factors is variably estimated. Genes polymorphisms associated with hyperhomocysteinemia, coagulation abnormalities, genetic factors involved in venous thrombosis leading to secondary CVI, represent the genetic background of this complex disease.
慢性静脉功能不全（CVI）是一个重要的医学和社会问题，对生活质量有重大影响。尽管在过去几十年中，人们对慢性静脉功能不全的发生和发展机制有了更好的理解，但遗传风险因素的作用尚未完全明确。许多因素参与了CVI的发病机制，如年龄、性别、遗传、久坐的生活方式。遗传因素的影响评估不一。与高同型半胱氨酸血症、凝血异常相关的基因多态性，以及导致继发性CVI的静脉血栓形成相关的遗传因素，构成了这种复杂疾病的遗传背景。
