The involvement of genetic factors in chronic venous insufficiency.

Chronic venous insufficiency (CVI) represents an important medical and social problem with a significant impact on the quality of life. Although the mechanisms of occurrence and development of chronic venous insufficiency became better understood in the last decades, the contribution of genetic risk factors is not precisely established. Many factors are involved in the etiopathogenesis of CVI, such as age, sex, heredity, sedentary life style. The impact of genetic factors is variably estimated. Genes polymorphisms associated with hyperhomocysteinemia, coagulation abnormalities, genetic factors involved in venous thrombosis leading to secondary CVI, represent the genetic background of this complex disease.