Stana Jan, Maver Uroš, Potočnik Uroš
Specialist in Vascular Surgery; Schön Klinik Vogtareuth, Klinik für operative und interventionelle Gefäßchirurgie, Krankenhausstraße 20, DE-83569 Vogtareuth, Germany.
Head of Institute of Biomedical Sciences, Assistant Professor in Pharmacology and Toxicology; University of Maribor, Faculty of Medicine, Institute of Biomedical Sciences, Taborska ulica 8, SI-2000 Maribor, Slovenia. University of Maribor, Faculty of Medicine, Department of Pharmacology, Taborska ulica 8, SI-2000 Maribor, Slovenia.
J Wound Care. 2019 Feb 2;28(2):59-65. doi: 10.12968/jowc.2019.28.2.59.
Chronic wounds represent a major socioeconomic problem. Chronic venous ulceration is one of the least well-understood types of chronic wounds. A chronic venous ulcer arises as a result of chronic venous insufficiency (CVI), which affects approximately 10-35% of people in the developed world, yet not all people with CVI develop ulceration. The question of why some patients with CVI develop chronic ulceration and others do not, still remains unanswered. Risk factors for the development of chronic ulceration are poorly understood and include age, residual iliofemoral vein obstruction, residual deep incompetence, persistent venous hypertension, obesity and genetics. The genetic aspects of CVI have only been vaguely evaluated. This paper reports on a literature review of the variation in genetic polymorphisms and gene expression associated with the development of a chronic venous ulceration.
慢性伤口是一个重大的社会经济问题。慢性静脉溃疡是最不为人所了解的慢性伤口类型之一。慢性静脉溃疡是慢性静脉功能不全（CVI）的结果，在发达国家，约10-35%的人受其影响，但并非所有CVI患者都会发生溃疡。为什么一些CVI患者会发展为慢性溃疡而另一些患者不会，这个问题仍然没有答案。慢性溃疡发展的风险因素了解甚少，包括年龄、残留的髂股静脉阻塞、残留的深部瓣膜功能不全、持续性静脉高压、肥胖和遗传因素。CVI的遗传方面仅得到了模糊的评估。本文报告了一篇关于与慢性静脉溃疡发展相关的基因多态性和基因表达变化的文献综述。
