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[黄斑及多焦视网膜电图在斯塔加特营养不良症诊断中的应用]

[Macular and multifocal electroretinography in the diagnosis of Stargardt's dystrophy].

作者信息

Zol'nikova I V, Karlova I Z, Rogatina E V

出版信息

Vestn Oftalmol. 2009 Jan-Feb;125(1):41-6.

Abstract

Retinal bioelectrical activity was studied in Stargardt's dystrophy from the data of multifocal and macular electroretinography (M-ERG) and retinal morphometry was carried out. The group of 11 patients (22 eyes) with the central form of Stargardt's dystrophy showed reductions in the retinal density of a bioelectric response of a P1 component, the amplitude of N1 and P1 components in the area of 0 to 16 degrees, as well as decreases in the amplitude of M-ERG a- and b-waves and in the retinal thickness in the macular region. The mixed Stargardt's dystrophy group was characterized by reductions in the retinal density of an electrical response of a P1 component, in the amplitude of N1 and P1 components in the entire posterior pole in the area of 0 to 32 degrees, as well as decreases in the a- and b-waves of M-ERG, photopic, scotopic, and mixed ERG; the lowered retinal thickness was found in the foveal and parafoveal regions. A statistically significant relationship was established between the morphometric indices of the volume of the central retina, the amplitude of M-ERG b-wave, and the moderate retinal density of P1 component bioelectrical activity in the central regions.

摘要

通过多焦视网膜电图(M-ERG)数据研究了Stargardt病的视网膜生物电活动,并进行了视网膜形态测量。11例(22只眼)中心型Stargardt病患者组显示,在0至16度区域,P1成分生物电反应的视网膜密度降低,N1和P1成分的振幅降低,同时M-ERG a波和b波的振幅以及黄斑区视网膜厚度降低。混合型Stargardt病组的特征是,在0至32度区域,整个后极区P1成分电反应的视网膜密度降低,N1和P1成分的振幅降低,同时M-ERG、明视视网膜电图、暗视视网膜电图和混合视网膜电图的a波和b波降低;在中央凹和中央凹旁区域发现视网膜厚度降低。在中央视网膜体积的形态测量指标、M-ERG b波的振幅和中央区域P1成分生物电活动的适度视网膜密度之间建立了统计学上的显著关系。

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