Zheng Hua-chuan, Yan Lei, Cui Lei, Guan Yi-fu, Takano Yasuo
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, PR China.
BMC Infect Dis. 2009 Mar 11;9:28. doi: 10.1186/1471-2334-9-28.
John Cunningham virus (JCV) constitutes a family of polyoma viruses, which plays important roles in the progressive multifocal leukoencephalopathy (PML) and tumorigenesis. However, no bibliometric investigation has been reported to guide the researchers and potential readers.
Papers were collected from database Sci-expanded and Pubmed until May 22, 2008. The highly-productive authors, institutes and countries, highly-cited authors and journals were ranked. The highly-cited articles were subjected to co-citation and chronological analysis with highly-frequent MeSH words for co-occurrence analysis.
Until now, 1785 articles about JCV were indexed in Sci-expanded and 1506 in Pubmed. The main document type was original article. USA, Japan and Italy were the largest three producers about JCV. Temple University published 128 papers and ranked the top, followed by University of Tokyo. Khalili K and Yogo Y became the core authors due to more than 20 documents produced. Journal of Neurovirology published more than 15 papers and ranked the top. Padgett BL and Berger JR were the first two highly-cited authors. Journal of Virology and Journal of Neurovirology respectively ranked to the first two highly-cited journals. These top highly-cited articles were divided into 5 aspects: (1) The correlation between JC virus and tumors; (2) Causal correlation of JCV with PML; (3) Polyoma virus infection and its related diseases in renal-allograft recipients; (4) Detection of JCV antibody, oncogene and its encoding protein; (5) Genetics and molecular biology of JCV. The MeSH/subheadings were classified into five groups: (1) JCV and virus infectious diseases; (2) JCV pathogenicity and pathological appearance of PML; (3) JCV isolation and detection; (4) Immunology of JCV and PML; (5) JCV genetics and tumors.
JCV investigation mainly focused on its isolation and detection, as well as its correlation with PML and tumors. Establishment of transgenic animal model using JCV T antigen would be a hopeful and useful project in the further study.
约翰·坎宁安病毒（JCV）属于多瘤病毒家族，在进行性多灶性白质脑病（PML）和肿瘤发生中起重要作用。然而，尚未有文献计量学研究报告来指导研究人员和潜在读者。
从数据库Sci-expanded和Pubmed收集截至2008年5月22日的论文。对高产作者、机构和国家、高被引作者和期刊进行排名。对高被引文章与高频医学主题词（MeSH）进行共引和时间分析以进行共现分析。
截至目前，Sci-expanded收录了1785篇关于JCV的文章，Pubmed收录了1506篇。主要文献类型为原创文章。美国、日本和意大利是关于JCV的最大三个产出国。天普大学发表了128篇论文，排名第一，其次是东京大学。卡里利·K和与良·Y因发表超过20篇文献而成为核心作者。《神经病毒学杂志》发表了超过15篇论文，排名第一。帕吉特·BL和伯杰·JR是前两位高被引作者。《病毒学杂志》和《神经病毒学杂志》分别排名前两位高被引期刊。这些顶级高被引文章分为5个方面：（1）JC病毒与肿瘤的相关性；（2）JCV与PML的因果关系；（3）肾移植受者中的多瘤病毒感染及其相关疾病；（4）JCV抗体、癌基因及其编码蛋白的检测；（5）JCV的遗传学和分子生物学。医学主题词/副主题词分为五组：（1）JCV与病毒感染性疾病；（2）JCV致病性和PML的病理表现；（3）JCV分离与检测；（4）JCV和PML的免疫学；（5）JCV遗传学与肿瘤。
JCV研究主要集中在其分离与检测，以及与PML和肿瘤的相关性。利用JCV T抗原建立转基因动物模型将是进一步研究中一个有希望且有用的项目。
