Christenson G A, Mackenzie T B, Mitchell J E, Callies A L
Department of Psychiatry, University of Minnesota, Minneapolis 55455.
Am J Psychiatry. 1991 Nov;148(11):1566-71. doi: 10.1176/ajp.148.11.1566.
It has been proposed by some investigators that trichotillomania, a disorder of chronic hair pulling, is a variant of obsessive-compulsive disorder, and some studies have suggested that the antiobessional agents clomipramine and fluoxetine are useful in treating this disorder. The authors investigated the efficacy of fluoxetine in the treatment of trichotillomania.
Twenty-one adult chronic hair pullers were recruited into an 18-week placebo-controlled, double-blind crossover study of fluoxetine, in doses up to 80 mg/day. The fluoxetine and placebo treatment phases consisted of 6-week trials of each agent separated by a 5-week washout period. Fifteen subjects (14 female and one male) completed the study; an additional female subject dropped out at 16 weeks after developing a drug reaction.
No significant Drug by Period interactions were found in weekly subject ratings of hair pulling, weekly subject ratings of the urge to pull hair, weekly assessments of the number of hair-pulling episodes, or the estimated amount of hair pulled per week.
The short-term efficacy of fluoxetine in the treatment of trichotillomania was not demonstrated in this study.
一些研究人员提出，拔毛癖这一慢性拔毛障碍是强迫症的一种变体，并且一些研究表明抗强迫症药物氯米帕明和氟西汀对治疗该障碍有效。作者调查了氟西汀治疗拔毛癖的疗效。
招募了21名成年慢性拔毛者，进行一项为期18周的氟西汀安慰剂对照、双盲交叉研究，剂量最高达80毫克/天。氟西汀和安慰剂治疗阶段各为期6周，两种药物治疗之间有5周的洗脱期。15名受试者（14名女性和1名男性）完成了研究；另有一名女性受试者在出现药物反应后于第16周退出。
在受试者每周的拔毛评分、每周的拔毛冲动评分、每周对拔毛发作次数的评估或每周估计的拔毛量方面，未发现药物与时期之间的显著交互作用。
本研究未证明氟西汀治疗拔毛癖的短期疗效。
