一项关于氟西汀治疗拔毛癖疗效的长期、双盲、安慰剂对照交叉试验。
A long-term, double-blind, placebo-controlled crossover trial of the efficacy of fluoxetine for trichotillomania.
作者信息
Streichenwein S M, Thornby J I
机构信息
Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.
出版信息
Am J Psychiatry. 1995 Aug;152(8):1192-6. doi: 10.1176/ajp.152.8.1192.
OBJECTIVE
The authors' objective was to determine the efficacy of fluoxetine at high doses for the treatment of trichotillomania in a long-term, double-blind, placebo-controlled crossover trial.
METHOD
Twenty-three adult chronic hair pullers agreed to take part in the trial, taking fluoxetine doses of up to 80 mg/day. The 31-week trial consisted of a 2-week washout phase, a first treatment phase of 12 weeks, a 5-week washout phase, and a crossover second treatment phase of 12 weeks. Sixteen patients (14 women and two men) completed the trial.
RESULTS
There were no significant differences between fluoxetine and placebo treatments for the measures of weekly severity of hair pulling, weekly severity of urge to pull, daily hair counts (or estimated hair pulled), or days of hair pulling.
CONCLUSIONS
The efficacy of fluoxetine in the treatment of trichotillomania was not demonstrated in this study.
目的
作者的目的是在一项长期、双盲、安慰剂对照的交叉试验中确定高剂量氟西汀治疗拔毛癖的疗效。
方法
23名成年慢性拔毛者同意参与试验，服用剂量高达80毫克/天的氟西汀。这项为期31周的试验包括一个为期2周的洗脱期、一个为期12周的首次治疗期、一个为期5周的洗脱期以及一个为期12周的交叉第二次治疗期。16名患者（14名女性和2名男性）完成了试验。
结果
在每周拔毛严重程度、每周拔毛冲动严重程度、每日毛发计数（或估计拔下的毛发）或拔毛天数的测量方面，氟西汀治疗与安慰剂治疗之间没有显著差异。
结论
本研究未证明氟西汀治疗拔毛癖的疗效。
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