Department of Internal Medicine, Section Clinical & Experimental Immunology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
Autoimmun Rev. 2009 Sep;9(1):53-7. doi: 10.1016/j.autrev.2009.03.001. Epub 2009 Mar 11.
While the involvement of T cells in atherosclerosis is nowadays well accepted, little is known about the role of B cells. Obviously, B cells as the source of antibodies, in particular antibodies to oxLDL, have gained a lot of attention in atherosclerosis. In addition, B cells do harbour other functions in adaptive immunity. In this review, we provide an overview of the current knowledge on both the role of B cells and antibodies, i.e., anti-oxLDL antibodies, in atherosclerosis. It appears that B cells and also anti-oxLDL antibodies may comprise pro- and anti-atherogenic effects. Therefore, the establishment of effective therapy, targeting B cells or anti-oxLDL antibodies, warrants further research to unravel these opposite effects.
虽然 T 细胞在动脉粥样硬化中的作用现在已经被广泛接受，但 B 细胞的作用却知之甚少。显然，B 细胞作为抗体的来源，特别是针对 oxLDL 的抗体，在动脉粥样硬化中引起了广泛关注。此外，B 细胞在适应性免疫中还具有其他功能。在这篇综述中，我们概述了目前关于 B 细胞及其抗体（即抗 oxLDL 抗体）在动脉粥样硬化中的作用的知识。似乎 B 细胞和抗 oxLDL 抗体都可能具有促动脉粥样硬化和抗动脉粥样硬化的作用。因此，为了阐明这些相反的作用，需要进一步研究针对 B 细胞或抗 oxLDL 抗体的有效治疗方法。
