动脉粥样硬化与免疫细胞的作用。
Atherosclerosis and the role of immune cells.
作者信息
Ilhan Fulya, Kalkanli Sevgi Tas
机构信息
Fulya Ilhan, Department of Immunology, Faculty of Medicine, University of Firat, 23200 Elazıg, Turkey.
出版信息
World J Clin Cases. 2015 Apr 16;3(4):345-52. doi: 10.12998/wjcc.v3.i4.345.
Abstract
Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon (IFN)-α and β are generated upon the activation of toll-like receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immune cells in the atherosclerosis.
摘要
动脉粥样硬化是一种由脂质，特别是低密度脂蛋白和白细胞引发的慢性炎症性疾病。在内皮细胞通过表达黏附分子和单核细胞被激活后，巨噬细胞和浆细胞样树突状细胞产生的炎性细胞因子，在Toll样受体9激活后会产生高水平的干扰素（IFN）-α和β，而T细胞，尤其是具有Th1型谱的T细胞，会产生促炎介质如IFN-γ，并上调巨噬细胞使其黏附于内皮并迁移至内膜。本综述详尽阐述了免疫细胞在动脉粥样硬化中的作用。
相似文献
1
Atherosclerosis and the role of immune cells.动脉粥样硬化与免疫细胞的作用。
World J Clin Cases. 2015 Apr 16;3(4):345-52. doi: 10.12998/wjcc.v3.i4.345.
2
Postprandial lipoproteins and the molecular regulation of vascular homeostasis.餐后脂蛋白与血管稳态的分子调控。
Prog Lipid Res. 2013 Oct;52(4):446-64. doi: 10.1016/j.plipres.2013.06.001. Epub 2013 Jun 15.
3
IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities.干扰素-α使单核细胞分化为表达Toll样受体7且具有强大功能活性的树突状细胞。
J Immunol. 2003 Oct 1;171(7):3385-93. doi: 10.4049/jimmunol.171.7.3385.
4
STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease.STAT1 作为一个新型治疗靶点，在 IFNγ、TLR4 和 IL-6 介导的动脉粥样硬化发病信号通路中起关键作用。
Cytokine Growth Factor Rev. 2011 Aug;22(4):211-9. doi: 10.1016/j.cytogfr.2011.06.003. Epub 2011 Jul 12.
5
Inflammatory mechanisms in atherosclerosis.动脉粥样硬化中的炎症机制。
J Thromb Haemost. 2009 Jul;7 Suppl 1:328-31. doi: 10.1111/j.1538-7836.2009.03416.x.
6
Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation.人类促炎1型和抗炎2型巨噬细胞对微生物抗原以及IFN-γ和CD40L介导的共刺激的表型和功能分析。
J Leukoc Biol. 2006 Feb;79(2):285-93. doi: 10.1189/jlb.0105015. Epub 2005 Dec 5.
7
Adaptation to replating of dendritic cells synergizes with Toll-like receptor stimuli and enhances the pro-inflammatory cytokine profile.树突状细胞再铺板的适应性与Toll样受体刺激协同作用，并增强促炎细胞因子谱。
Cytotherapy. 2016 Jul;18(7):902-10. doi: 10.1016/j.jcyt.2016.03.298. Epub 2016 May 18.
8
Inflammation and atherosclerosis.炎症与动脉粥样硬化。
Annu Rev Pathol. 2006;1:297-329. doi: 10.1146/annurev.pathol.1.110304.100100.
9
[Immune factors in atherosclerosis].[动脉粥样硬化中的免疫因素]
Ann Ital Med Int. 2005 Apr-Jun;20(2):81-9.
10
Atherosclerosis as an inflammatory disease.动脉粥样硬化作为一种炎症性疾病。
Curr Pharm Des. 2012;18(28):4266-88. doi: 10.2174/138161212802481237.
引用本文的文献
1
CD8 T-Cell Deletion Suppressed the Development of Injury-Induced Experimental Neointimal Hyperplasia in Mice With or Without Chronic Stress.CD8 T细胞缺失抑制了有或无慢性应激的小鼠损伤诱导的实验性内膜增生的发展。
FASEB J. 2025 Sep 30;39(18):e71044. doi: 10.1096/fj.202502380R.
2
Single cell RNA sequencing of haematopoietic cells in fresh and frozen human atheroma tissue.新鲜和冷冻的人类动脉粥样硬化组织中造血细胞的单细胞RNA测序
Cardiovasc Res. 2025 Apr 29;121(3):396-404. doi: 10.1093/cvr/cvaf014.
3
Dietary ellagic acid blocks inflammation-associated atherosclerotic plaque formation in cholesterol-fed apoE-deficient mice.膳食鞣花酸可阻止喂食胆固醇的载脂蛋白E缺乏小鼠体内与炎症相关的动脉粥样硬化斑块形成。
Nutr Res Pract. 2024 Oct;18(5):617-632. doi: 10.4162/nrp.2024.18.5.617. Epub 2024 Jul 10.
4
Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection.钙卫蛋白阻断可抑制腹膜透析相关细菌性感染后的长期血管病变。
Front Cell Infect Microbiol. 2023 Nov 29;13:1285193. doi: 10.3389/fcimb.2023.1285193. eCollection 2023.
5
RNA Sequencing of Whole Blood in Premature Coronary Artery Disease: Identification of Novel Biomarkers and Involvement of T Cell Imbalance.全血 RNA 测序在早发冠状动脉疾病中的应用：新型生物标志物的鉴定及 T 细胞失衡的参与。
J Cardiovasc Transl Res. 2024 Jun;17(3):638-647. doi: 10.1007/s12265-023-10465-8. Epub 2023 Dec 1.
6
Therapeutic targeting of chronic kidney disease-associated DAMPs differentially contributing to vascular pathology.靶向治疗与慢性肾脏病相关 DAMPs，以差异化地改善血管病变。
Front Immunol. 2023 Oct 2;14:1240679. doi: 10.3389/fimmu.2023.1240679. eCollection 2023.
7
Immune landscape and regulatory mechanisms in human atherosclerotic coronary plaques: Evidence from single-cell and bulk transcriptomics.人类动脉粥样硬化性冠状动脉斑块中的免疫格局和调控机制：来自单细胞和整体转录组学的证据
Heliyon. 2023 Aug 22;9(9):e19392. doi: 10.1016/j.heliyon.2023.e19392. eCollection 2023 Sep.
8
Increased extracellular vesicles (EVs) related to T cell-mediated inflammation and vascular function in familial hypercholesterolemia.家族性高胆固醇血症中与T细胞介导的炎症和血管功能相关的细胞外囊泡增加。
Atheroscler Plus. 2023 Jun 22;53:16-25. doi: 10.1016/j.athplu.2023.06.004. eCollection 2023 Sep.
9
Current Biomarkers for Carotid Artery Stenosis: A Comprehensive Review of the Literature.颈动脉狭窄的当前生物标志物：文献综述
Metabolites. 2023 Aug 5;13(8):919. doi: 10.3390/metabo13080919.
10
Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1-directed novel therapeutics.靶向动脉粥样硬化内皮血管细胞黏附分子-1：血管细胞黏附分子-1 导向新型治疗药物的发现和开发。
Cardiovasc Res. 2023 Oct 24;119(13):2278-2293. doi: 10.1093/cvr/cvad130.
本文引用的文献
1
The role of monocytes in angiogenesis and atherosclerosis.单核细胞在血管生成和动脉粥样硬化中的作用。
J Am Coll Cardiol. 2014;63(1):1-11. doi: 10.1016/j.jacc.2013.09.019. Epub 2013 Oct 16.
2
Immunity, atherosclerosis and cardiovascular disease.免疫、动脉粥样硬化与心血管疾病。
BMC Med. 2013 May 1;11:117. doi: 10.1186/1741-7015-11-117.
3
Inflammation and immune system interactions in atherosclerosis.动脉粥样硬化中的炎症和免疫系统相互作用。
Cell Mol Life Sci. 2013 Oct;70(20):3847-69. doi: 10.1007/s00018-013-1289-1. Epub 2013 Feb 21.
4
Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.白细胞在动脉粥样硬化、心肌梗死和心力衰竭中的作用。
Science. 2013 Jan 11;339(6116):161-6. doi: 10.1126/science.1230719.
5
T lymphocyte autoreactivity in inflammatory mechanisms regulating atherosclerosis.调节动脉粥样硬化的炎症机制中的T淋巴细胞自身反应性。
ScientificWorldJournal. 2012;2012:157534. doi: 10.1100/2012/157534. Epub 2012 Dec 10.
6
The biological role of inflammation in atherosclerosis.炎症在动脉粥样硬化中的生物学作用。
Can J Cardiol. 2012 Nov-Dec;28(6):631-41. doi: 10.1016/j.cjca.2012.06.023. Epub 2012 Sep 15.
7
Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis.前列腺素 I2 信号转导驱动 Th17 分化并加重实验性自身免疫性脑脊髓炎。
PLoS One. 2012;7(5):e33518. doi: 10.1371/journal.pone.0033518. Epub 2012 May 10.
8
Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.巨噬细胞在动脉粥样硬化中的多种作用：从炎症生物学到生物标志物发现。
Mediators Inflamm. 2012;2012:693083. doi: 10.1155/2012/693083. Epub 2012 Apr 11.
9
Regulatory T cells and IL-10 levels are reduced in patients with vulnerable coronary plaques.易损斑块患者的调节性 T 细胞和 IL-10 水平降低。
Atherosclerosis. 2012 Jun;222(2):519-23. doi: 10.1016/j.atherosclerosis.2012.03.016. Epub 2012 Apr 6.
10
Lymphocytes in atherosclerosis.动脉粥样硬化中的淋巴细胞。
Clin Chim Acta. 2012 Oct 9;413(19-20):1562-8. doi: 10.1016/j.cca.2012.04.031. Epub 2012 May 4.
Zotero 插件