Ilhan Fulya, Kalkanli Sevgi Tas
Fulya Ilhan, Department of Immunology, Faculty of Medicine, University of Firat, 23200 Elazıg, Turkey.
World J Clin Cases. 2015 Apr 16;3(4):345-52. doi: 10.12998/wjcc.v3.i4.345.
Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon (IFN)-α and β are generated upon the activation of toll-like receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immune cells in the atherosclerosis.
动脉粥样硬化是一种由脂质，特别是低密度脂蛋白和白细胞引发的慢性炎症性疾病。在内皮细胞通过表达黏附分子和单核细胞被激活后，巨噬细胞和浆细胞样树突状细胞产生的炎性细胞因子，在Toll样受体9激活后会产生高水平的干扰素（IFN）-α和β，而T细胞，尤其是具有Th1型谱的T细胞，会产生促炎介质如IFN-γ，并上调巨噬细胞使其黏附于内皮并迁移至内膜。本综述详尽阐述了免疫细胞在动脉粥样硬化中的作用。
