Renzullo P O, McNeil J G, Gardner L I, Brundage J F
Department of Epidemiology, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Am J Public Health. 1991 Oct;81(10):1280-4. doi: 10.2105/ajph.81.10.1280.
A natural history study of human immunodeficiency virus (HIV) disease was carried out among 1575 HIV-infected US Army men and 6220 demographically similar uninfected soldiers. Inpatient morbidity occurring up to 8 years prior to the date of HIV infection diagnosis among those men who became HIV infected was evaluated for both groups.
Incidence density rates were calculated for hospital admissions. Poisson regression was used to assess the trend in hospital admissions among those subsequently diagnosed with HIV infection. Prevalence ratios for discharge diagnoses were also calculated.
Sixteen diagnoses/diagnosis categories occurred statistically more frequently among subsequently HIV diagnosed individuals than among those who remained uninfected. Among these were hepatitis B and abscess of anal/rectal region (6 to 8 years prior to HIV infection diagnosis); unspecified viral infection, enlarged lymph nodes, syphilis (3 to 5 years prior to HIV infection diagnosis); and diagnoses suggestive of acute retroviral syndrome (1 to 2 years prior to HIV infection diagnosis).
Data such as these may provide useful information to HIV surveillance efforts regarding patterns of morbidity experienced prior to HIV infection as well as to health care providers regarding patients at high risk for becoming infected with HIV.
对1575名感染人类免疫缺陷病毒（HIV）的美国陆军士兵和6220名人口统计学特征相似的未感染士兵进行了HIV疾病自然史研究。对两组中那些后来感染HIV的男性在HIV感染诊断日期前8年内发生的住院发病率进行了评估。
计算住院率的发病密度。采用泊松回归评估随后被诊断为HIV感染的人群中住院率的趋势。还计算了出院诊断的患病率比值。
16种诊断/诊断类别在随后被诊断为HIV感染的个体中出现的频率在统计学上高于未感染个体。其中包括乙型肝炎和肛门/直肠区域脓肿（在HIV感染诊断前6至8年）；未明确的病毒感染、淋巴结肿大、梅毒（在HIV感染诊断前3至5年）；以及提示急性逆转录病毒综合征的诊断（在HIV感染诊断前1至2年）。
此类数据可能为HIV监测工作提供有关HIV感染前发病模式的有用信息，并为医疗保健提供者提供有关感染HIV高风险患者的信息。
