Harvey Kyle P, Adair James D, Isho Mayyas, Robinson Robert
Department of Surgery, St. Joseph Mercy Oakland Hospital, Pontiac, MI, USA.
Am J Surg. 2009 Aug;198(2):231-6. doi: 10.1016/j.amjsurg.2008.10.015. Epub 2009 Mar 12.
This study examined whether systemic infusion of lidocaine, a local anesthetic with anti-inflammatory properties, can decrease surgical pain, length of postsurgical ileus, and hospital stay.
Twenty-two patients at a community hospital were randomized into 2 groups. Subjects were allocated to receive either lidocaine or a placebo infusion for the first 24 hours after surgery.
Patients in the lidocaine group appeared to report less pain as reflected by a decrease in overall visual analogue scale pain scores 24 hours after surgery. The return of flatus after surgery was not considered significant (lidocaine 68.2 +/- 9.7 hours vs placebo 86.9 +/- 13.6 hours; P = .2802). The return of bowel movement after surgery was considered significant (lidocaine 88.3 +/- 6.08 hours vs placebo group 116 +/- 10.1 hours; P = .0286). The lidocaine group was discharged by mean day 3.76 +/- .24 versus placebo at mean day 4.93 +/- .42; P = .0277.
Patients in the lidocaine group had bowel movements >24 hours earlier than those in the placebo group and were discharged earlier.
本研究旨在探讨全身输注利多卡因（一种具有抗炎特性的局部麻醉剂）是否能减轻手术疼痛、缩短术后肠梗阻时间及住院时间。
一家社区医院的22例患者被随机分为2组。受试者在术后的头24小时内被分配接受利多卡因或安慰剂输注。
利多卡因组患者在术后24小时的总体视觉模拟量表疼痛评分降低，这表明他们报告的疼痛似乎较少。术后肠鸣音恢复情况无显著差异（利多卡因组为68.2±9.7小时，安慰剂组为86.9±13.6小时；P = 0.2802）。术后排便恢复情况有显著差异（利多卡因组为88.3±6.08小时，安慰剂组为116±10.1小时；P = 0.0286）。利多卡因组平均在第3.76±0.24天出院，而安慰剂组平均在第4.93±0.42天出院；P = 0.0277。
利多卡因组患者的排便时间比安慰剂组早24小时以上，且出院更早。
