Vanden Bussche J, Noppe H, Verheyden K, Wille K, Pinel G, Le Bizec B, De Brabander H F
Ghent University, Faculty of Veterinary Medicine, Research Group of Veterinary Public Health and Zoonoses, Laboratory Chemical Analysis, Salisburylaan 133, B-9820 Merelbeke, Belgium.
Anal Chim Acta. 2009 Apr 1;637(1-2):2-12. doi: 10.1016/j.aca.2008.08.027. Epub 2008 Aug 29.
Thyreostatic drugs (TS), illegally administrated to livestock for fattening purposes, are banned in the European Union since 1981 (Council Directive 81/602/EC). This paper reviews the trends in the analytical approaches for the determination of TS drugs in biological matrices. After a brief introduction on the different groups of compounds with a thyreostatic action, the most relevant legislation regarding the residue control of these compounds is presented. An overview of the analytical possibilities for the determination of TS in animal matrices, covering sample extraction, purification, separation techniques and detection methods is provided. Additionally, a brief outline of animal experiments is described that illustrates the excretion and distribution profiles of TS residues. Finally, the novel developments in TS analysis are highlighted. Also the possible semi-endogenous status of thiouracil is discussed.
自1981年起，欧盟禁止将用于育肥目的而非法给牲畜使用的抗甲状腺药物（TS）（理事会指令81/602/EC）。本文综述了生物基质中抗甲状腺药物测定分析方法的发展趋势。在简要介绍具有抗甲状腺作用的不同化合物组之后，介绍了有关这些化合物残留控制的最相关法规。概述了动物基质中抗甲状腺药物测定的分析可能性，包括样品提取、净化、分离技术和检测方法。此外，还描述了动物实验的简要概况，阐明了抗甲状腺药物残留的排泄和分布情况。最后，强调了抗甲状腺药物分析的新进展。还讨论了硫脲可能的半内源性状态。
