Woźniak Barbara, Matraszek-Żuchowska Iwona, Sielska Katarzyna, Witek Sebastian, Posyniak Andrzej, Niemczuk Krzysztof, Żmudzki Jan
Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland.
J Vet Res. 2018 Dec 31;62(4):511-517. doi: 10.2478/jvetres-2018-0077. eCollection 2018 Dec.
In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011-2017.
The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method.
In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants.
The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.
在欧盟，自1981年起，根据理事会指令81/602/EEC，已禁止在育肥屠宰动物中使用抗甲状腺药物。为保护消费者健康免受不必要的残留影响，并符合指令96/23，每个欧盟国家必须监测动物源性样品中的抗甲状腺药物。本文介绍了2011 - 2017年在波兰进行的抗甲状腺药物残留研究结果。
检测材料为尿液（n = 3491）、饮用水（n = 127）和肌肉样本（n = 349），这些样本由兽医卫生检查员根据国家残留控制计划在全国的屠宰场和农场正式采集。使用液相色谱串联质谱法通过认可的方法检测样本中是否存在甲巯咪唑、硫脲嘧啶、甲基硫脲嘧啶、丙基硫脲嘧啶和苯基硫脲嘧啶。
在4份牛尿液样本和3份猪尿液样本中，硫脲嘧啶浓度超过了允许值。在1份猪尿液样本中发现了甲基硫脲嘧啶和丙基硫脲嘧啶。尿液样本中存在硫脲嘧啶及其衍生物很可能是由于给动物喂食了含有十字花科植物的饲料。
研究结果表明，在波兰，抗甲状腺药物并非用于屠宰动物的合成代谢目的。
