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Dasatinib in the management of lymphoid blast crisis of Philadelphia-positive chronic myeloid leukemia with multiple extra-medullary and intracranial localizations.

作者信息

Alimena Giuliana, Breccia Massimo, Latagliata Roberto, Grammatico Sara, Matturro Angela, Capria Saveria, De Propris Maria Stefania, Diverio Daniela, Meloni Giovanna

出版信息

Leuk Res. 2009 Aug;33(8):e134-6. doi: 10.1016/j.leukres.2009.02.018. Epub 2009 Mar 14.

DOI:10.1016/j.leukres.2009.02.018
PMID:19286256
Abstract
摘要

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Dasatinib in the management of lymphoid blast crisis of Philadelphia-positive chronic myeloid leukemia with multiple extra-medullary and intracranial localizations.达沙替尼用于治疗伴有多处髓外和颅内病变的费城染色体阳性慢性髓性白血病的淋巴母细胞危象。
Leuk Res. 2009 Aug;33(8):e134-6. doi: 10.1016/j.leukres.2009.02.018. Epub 2009 Mar 14.
2
Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia.达沙替尼：一种用于治疗慢性粒细胞白血病和费城染色体阳性急性淋巴细胞白血病的酪氨酸激酶抑制剂。
Clin Ther. 2007 Nov;29(11):2289-308. doi: 10.1016/j.clinthera.2007.11.005.
3
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias.达沙替尼用于伊马替尼耐药的费城染色体阳性白血病。
N Engl J Med. 2006 Jun 15;354(24):2531-41. doi: 10.1056/NEJMoa055229.
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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.BCR-ABL酪氨酸激酶特异性抑制剂在伴有费城染色体的慢性髓性白血病急变期和急性淋巴细胞白血病中的活性
N Engl J Med. 2001 Apr 5;344(14):1038-42. doi: 10.1056/NEJM200104053441402.
5
Successful prior treatment with dasatinib followed by stem cell transplantation in a patient with CML in blastic crisis with a BCR-ABL mutation.在伴有 BCR-ABL 突变的急变期 CML 患者中，先用达沙替尼进行成功的既往治疗，然后进行干细胞移植。
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Dasatinib combined with weekly administration of vincristine as effective therapy in sudden or resistant Ph+ lymphoid blast crisis of chronic myeloid leukaemia.达沙替尼联合每周一次的长春新碱给药可有效治疗慢性髓性白血病的突发或难治性Ph+淋巴细胞母细胞危象。
Br J Haematol. 2012 Dec;159(5):612-3. doi: 10.1111/bjh.12079. Epub 2012 Oct 9.
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FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.FTY720，一种治疗急变期慢性粒细胞白血病和费城染色体阳性急性淋巴细胞白血病的新选择。
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[Research advance on molecular genetics of CML blast crisis].[慢性粒细胞白血病急变期的分子遗传学研究进展]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Feb;16(1):217-21.
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Clofarabine-based regimen as useful bridge therapy for allogeneic transplantation in myeloid blast crisis of Philadelphia-positive chronic myeloid leukemia resistant to imatinib and dasatinib.基于氯法拉滨的方案作为伊马替尼和达沙替尼耐药的费城染色体阳性慢性髓性白血病髓系原始细胞危象异基因移植的有效桥接治疗。
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Sequential mutations causing resistance to both Imatinib Mesylate and Dasatinib in a chronic myeloid leukaemia patient progressing to lymphoid blast crisis.一名慢性髓性白血病进展为淋巴细胞母细胞危象的患者中导致对甲磺酸伊马替尼和达沙替尼均耐药的序贯突变
Leuk Res. 2008 Apr;32(4):673-4. doi: 10.1016/j.leukres.2007.08.008. Epub 2007 Sep 24.

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Non-conducting functions of ion channels: The case of integrin-ion channel complexes.离子通道的非传导功能：整合素-离子通道复合物的情况。
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Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer's disease.人脑中 KCNB1 通道的氧化作用和阿尔茨海默病小鼠模型。
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Extramedullary Involvement by Chronic Myelogeneous Leukemia in Five Patients With Unusual Clinicopathologic Features: A Review of the Effectiveness of Tyrosine Kinase Inhibitors.5例具有不寻常临床病理特征的慢性髓性白血病髓外浸润：酪氨酸激酶抑制剂疗效综述
J Clin Med Res. 2016 Jun;8(6):480-5. doi: 10.14740/jocmr2566w. Epub 2016 May 25.
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Severe thrombocytopenia after dasatinib treatment in a patient with Philadelphia chromosome-positive chronic myeloid leukemia.一名费城染色体阳性慢性髓性白血病患者在接受达沙替尼治疗后出现严重血小板减少症。
Onco Targets Ther. 2015 Apr 24;8:955-7. doi: 10.2147/OTT.S83961. eCollection 2015.
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Dasatinib as the salvage therapy for chronic myeloid leukemia with blast crisis and central nervous system involvement: A case report.达沙替尼作为慢性髓性白血病急变期合并中枢神经系统受累的挽救治疗：一例报告。
Oncol Lett. 2015 Apr;9(4):1957-1961. doi: 10.3892/ol.2015.2928. Epub 2015 Feb 3.
7
The role of dasatinib in the management of chronic myeloid leukemia.达沙替尼在慢性髓性白血病治疗中的作用。
Drug Des Devel Ther. 2015 Feb 9;9:773-9. doi: 10.2147/DDDT.S80207. eCollection 2015.
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Philadelphia chromosome-positive acute lymphoblastic leukemia with extramedullary and meningeal relapse after allogeneic hematopoietic stem cell transplantation that was successfully treated with dasatinib.费城染色体阳性急性淋巴细胞白血病，异基因造血干细胞移植后发生髓外和脑膜复发，使用达沙替尼成功治疗。
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Extramedullary blast crisis of chronic myelogenous leukemia as an initial presentation.慢性髓性白血病髓外原始细胞危象作为首发表现
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