Tsukamoto Shokichi, Ota Satoshi, Ohwada Chikako, Takeda Yusuke, Takeuchi Masahiro, Sakaida Emiko, Shimizu Naomi, Yokote Koutaro, Iseki Tohru, Nakaseko Chiaki
Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Department of Pathology, Chiba University Hospital, Chiba, Japan.
Leuk Res Rep. 2013 Aug 13;2(2):67-9. doi: 10.1016/j.lrr.2013.07.002. eCollection 2013.
Extramedullary blast crisis of chronic myelogenous leukemia (CML) is defined as the development of extramedullary disease caused by the infiltration of blasts regardless of proliferation of blasts in the bone marrow. The onset of extramedullary blast crisis in the newly diagnosed patients is known to be extremely rare. Here, we present a case of extramedullary blast crisis of CML as an initial presentation in a 17-year-old female presenting with pain in the left femur tumor. This case was treated successfully with dasatinib and allogeneic hematopoietic stem cell transplantation, with achievement of long-term remission.
慢性髓性白血病（CML）的髓外原始细胞危象定义为，无论骨髓中原始细胞的增殖情况如何，由原始细胞浸润引起的髓外疾病的发生。已知新诊断患者中髓外原始细胞危象的发病极为罕见。在此，我们报告一例CML髓外原始细胞危象，作为一名17岁左股骨肿瘤疼痛女性的首发表现。该病例通过达沙替尼和异基因造血干细胞移植成功治疗，实现了长期缓解。
