Bouhaha R, Choquet H, Meyre D, Abid Kamoun H, Ennafaa H, Baroudi T, Sassi R, Vaxillaire M, Elgaaied A, Froguel P, Cauchi S
Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, 2092 Tunis, Tunisia.
Pathol Biol (Paris). 2010 Dec;58(6):426-9. doi: 10.1016/j.patbio.2009.01.003. Epub 2009 Mar 14.
The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele was associated with type 2 diabetes (T2D) in most populations worldwide. In individuals of European descent, the association with T2D was recently found to be modulated by obesity status. However, further studies are necessary to clarify if whether interaction exists among subjects of non-European descent. In the present study, we analyzed the association of rs7903146 with T2D in 90 nonobese (Body Mass Index [BMI] <25kg/m(2)), 171 overweight (25≤BMI<30kg/m(2)) et 98 obese (BMI≥30kg/m(2)) individuals from Tunisia. The T allele was nominally associated with T2D in nonobese subjects (Odds Ratio [OR]=3.24 [1.10-9.53], P=0.021) whereas no effect was detected in overweight (P=0.3) and obese (P=0.22) individuals. Consequently, the same risk allele decreased susceptibility to obesity in T2D subjects (OR=0.47 [0.23-0.94], P=0.029) but not in normoglycemic controls (P=0.44). When analyzed all together, no allelic association was observed with T2D (P=0.20) whereas an artefactual association with decreased obesity (0.59 [0.38-0.90], P=0.013) was detected. As in Europeans, TCF7L2 is therefore not a risk factor for obesity in Tunisians, but its effect on T2D risk is modulated by obesity. In conclusion, the TCF7L2 rs7903146 T allele is nominally associated with T2D susceptibility in nonobese individuals from Tunisia.
转录因子7样2（TCF7L2）基因rs7903146的T等位基因在全球大多数人群中与2型糖尿病（T2D）相关。在欧洲血统个体中，最近发现该基因与T2D的关联受肥胖状态调节。然而，有必要进行进一步研究以明确非欧洲血统个体之间是否存在相互作用。在本研究中，我们分析了突尼斯90名非肥胖者（体重指数[BMI]<25kg/m²）、171名超重者（25≤BMI<30kg/m²）和98名肥胖者（BMI≥30kg/m²）中rs7903146与T2D的关联。T等位基因在非肥胖受试者中与T2D呈名义上的关联（优势比[OR]=3.24[1.10 - 9.53]，P=0.021），而在超重者（P=0.3）和肥胖者（P=0.22）中未检测到影响。因此，相同的风险等位基因在T2D受试者中降低了肥胖易感性（OR=0.47[0.23 - 0.94]，P=0.029），但在血糖正常的对照组中未降低（P=0.44）。综合分析时，未观察到与T2D的等位基因关联（P=0.20），但检测到与肥胖降低的人为关联（0.59[0.38 - 0.90]，P=0.013）。与欧洲人一样，因此TCF7L2在突尼斯人当中不是肥胖的危险因素，但其对T2D风险的影响受肥胖调节。总之，TCF7L2基因rs7903146的T等位基因在突尼斯非肥胖个体中与T2D易感性呈名义上的关联。
