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乳酸乳球菌中染色体噬菌体抗性机制AbiV的激活与转移

Activation and transfer of the chromosomal phage resistance mechanism AbiV in Lactococcus lactis.

作者信息

Haaber Jakob, Moineau Sylvain, Hammer Karin

机构信息

Center for Systems Microbiology, DTU Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark.

出版信息

Appl Environ Microbiol. 2009 May;75(10):3358-61. doi: 10.1128/AEM.02538-08. Epub 2009 Mar 13.

DOI:10.1128/AEM.02538-08
PMID:19286782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2681626/
Abstract

AbiV is a chromosomally encoded phage resistance mechanism that is silent in the wild-type phage-sensitive strain Lactococcus lactis subsp. cremoris MG1363. Spontaneous phage-resistant mutants of L. lactis MG1363 were analyzed by reverse transcriptase PCR and shown to express AbiV. This expression was related to a reorganization in the upstream region of abiV. Transfer of abiV between two lactococcal strains, most likely by conjugation, was also demonstrated. To our knowledge, this is the first report of natural transfer of a chromosomally encoded phage resistance mechanism.

摘要

AbiV是一种染色体编码的噬菌体抗性机制，在野生型对噬菌体敏感的菌株乳酸乳球菌亚种cremoris MG1363中处于沉默状态。通过逆转录酶PCR分析了乳酸乳球菌MG1363的自发噬菌体抗性突变体，结果显示它们表达AbiV。这种表达与abiV上游区域的重组有关。还证明了abiV在两个乳球菌菌株之间的转移，最有可能是通过接合作用实现的。据我们所知，这是关于染色体编码的噬菌体抗性机制自然转移的首次报道。

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本文引用的文献

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Appl Environ Microbiol. 2009 Apr;75(8):2484-94. doi: 10.1128/AEM.02093-08. Epub 2009 Mar 6.
2
AbiV, a novel antiphage abortive infection mechanism on the chromosome of Lactococcus lactis subsp. cremoris MG1363.AbiV，一种在乳酸乳球菌乳脂亚种MG1363染色体上的新型抗噬菌体流产感染机制。
Appl Environ Microbiol. 2008 Nov;74(21):6528-37. doi: 10.1128/AEM.00780-08. Epub 2008 Sep 5.
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Abortive phage resistance mechanism AbiZ speeds the lysis clock to cause premature lysis of phage-infected Lactococcus lactis.流产性噬菌体抗性机制AbiZ加快裂解时钟，导致被噬菌体感染的乳酸乳球菌过早裂解。
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Sequence and comparative genomic analysis of lactococcal bacteriophages jj50, 712 and P008: evolutionary insights into the 936 phage species.乳酸乳球菌噬菌体jj50、712和P008的序列及比较基因组分析：对936噬菌体物种的进化见解
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