噬菌体-宿主军备竞赛：塑造微生物的进化。
The phage-host arms race: shaping the evolution of microbes.
机构信息
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
出版信息
Bioessays. 2011 Jan;33(1):43-51. doi: 10.1002/bies.201000071.
Abstract
Bacteria, the most abundant organisms on the planet, are outnumbered by a factor of 10 to 1 by phages that infect them. Faced with the rapid evolution and turnover of phage particles, bacteria have evolved various mechanisms to evade phage infection and killing, leading to an evolutionary arms race. The extensive co-evolution of both phage and host has resulted in considerable diversity on the part of both bacterial and phage defensive and offensive strategies. Here, we discuss the unique and common features of phage resistance mechanisms and their role in global biodiversity. The commonalities between defense mechanisms suggest avenues for the discovery of novel forms of these mechanisms based on their evolutionary traits.
摘要
细菌是地球上数量最多的生物，其数量是感染它们的噬菌体的 10 到 1 倍。面对噬菌体粒子的快速进化和更替，细菌已经进化出各种机制来逃避噬菌体的感染和杀伤，从而导致了一场进化军备竞赛。噬菌体和宿主的广泛共同进化导致了细菌和噬菌体防御和进攻策略的多样性。在这里，我们讨论了噬菌体抗性机制的独特和共同特征及其在全球生物多样性中的作用。防御机制的共性表明，可以根据它们的进化特征来发现这些机制的新形式。
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本文引用的文献
1
COEVOLUTION IN BACTERIAL-PLASMID POPULATIONS.细菌 - 质粒群体中的协同进化
Evolution. 1991 May;45(3):656-667. doi: 10.1111/j.1558-5646.1991.tb04336.x.
2
PHAGE-MEDIATED SELECTION AND THE EVOLUTION AND MAINTENANCE OF RESTRICTION-MODIFICATION.噬菌体介导的选择与限制修饰的进化及维持
Evolution. 1993 Apr;47(2):556-575. doi: 10.1111/j.1558-5646.1993.tb02113.x.
3
Self-targeting by CRISPR: gene regulation or autoimmunity?CRISPR 自我靶向：基因调控还是自身免疫？
Trends Genet. 2010 Aug;26(8):335-40. doi: 10.1016/j.tig.2010.05.008. Epub 2010 Jul 1.
4
Bacteriophage resistance mechanisms.噬菌体耐药机制。
Nat Rev Microbiol. 2010 May;8(5):317-27. doi: 10.1038/nrmicro2315. Epub 2010 Mar 29.
5
Antagonistic coevolution accelerates molecular evolution.拮抗协同进化加速了分子进化。
Nature. 2010 Mar 11;464(7286):275-8. doi: 10.1038/nature08798. Epub 2010 Feb 24.
6
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea.CRISPR 干扰：细菌和古菌中的 RNA 导向适应性免疫。
Nat Rev Genet. 2010 Mar;11(3):181-90. doi: 10.1038/nrg2749.
7
Self versus non-self discrimination during CRISPR RNA-directed immunity.CRISPR RNA 指导的免疫过程中的自我与非我区分。
Nature. 2010 Jan 28;463(7280):568-71. doi: 10.1038/nature08703. Epub 2010 Jan 13.
8
CRISPR/Cas, the immune system of bacteria and archaea.CRISPR/Cas，细菌和古菌的免疫系统。
Science. 2010 Jan 8;327(5962):167-70. doi: 10.1126/science.1179555.
9
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex.CRISPR RNA-Cas蛋白复合物介导的RNA引导的RNA切割
Cell. 2009 Nov 25;139(5):945-56. doi: 10.1016/j.cell.2009.07.040.
10
REBASE--a database for DNA restriction and modification: enzymes, genes and genomes.REBASE--一个用于 DNA 限制和修饰的数据库：酶、基因和基因组。
Nucleic Acids Res. 2010 Jan;38(Database issue):D234-6. doi: 10.1093/nar/gkp874. Epub 2009 Oct 21.
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