SimMLST：中性模型下多位点序列分型数据的模拟
SimMLST: simulation of multi-locus sequence typing data under a neutral model.
作者信息
Didelot Xavier, Lawson Daniel, Falush Daniel
机构信息
Department of Statistics, University of Warwick, Coventry, UK.
出版信息
Bioinformatics. 2009 Jun 1;25(11):1442-4. doi: 10.1093/bioinformatics/btp145. Epub 2009 Mar 13.
SUMMARY
Multi-locus sequence typing (MLST) is a widely used method of characterization of bacterial isolates. It has been applied to over 50,000 isolates in over 50 different species. Here, we present a coalescent method to jointly simulate MLST data and the clonal genealogy that gave rise to the sample.
AVAILABILITY AND IMPLEMENTATION
SimMLST was implemented in C++ and Qt4 for the graphical user interface. It is distributed under the terms of the GNU General Public License. Source code and binaries for Windows and Linux are available from (http://go.warwick.ac.uk/SimMLST). A user guide and a technical description of the algorithm are provided with the program.
摘要
多位点序列分型（MLST）是一种广泛用于细菌分离株鉴定的方法。它已应用于50多个不同物种的50000多个分离株。在此，我们提出一种合并方法，用于联合模拟MLST数据以及产生该样本的克隆谱系。
可用性与实现
SimMLST用C++和Qt4实现了图形用户界面。它根据GNU通用公共许可证的条款分发。Windows和Linux的源代码及二进制文件可从（http://go.warwick.ac.uk/SimMLST）获取。该程序提供了用户指南和算法的技术描述。
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