Xu Gaosi, Tu Weiping, Jiang Dongfeng, Xu Chengyun
Department of Nephrology, Second Affiliated Hospital, Nanchang University, No. 1 Minde Road, Nanchang, PR China.
Nephron Clin Pract. 2009;111(4):c223-8. doi: 10.1159/000208990. Epub 2009 Mar 14.
Tripterygium wilfordii Hook F (TwHF) is a Chinese herbal medicine with immunosuppressive effects and an established history of use in the treatment of inflammatory and autoimmune diseases. We have carried out a meta-analysis of randomized controlled trials (RCTs) and quasi-RCTs which assessed the effectiveness of TwHF in the treatment for idiopathic refractory nephrotic syndrome (IRNS). After reading the full text, only three RCTs or quasi-RCTs meeting our inclusion criteria were selected. Our meta-analysis indicated that TwHF has beneficial effects on the remission of IRNS. There was no significant publication bias in the meta-analysis studies. However, studies with a larger sample size and including patients with both a mild and severe histopathological change involvement separately are needed to assess the effects of TwHF in IRNS patients before exact conclusions can be drawn.
雷公藤(Tripterygium wilfordii Hook F,TwHF)是一种具有免疫抑制作用的中药,在治疗炎症性和自身免疫性疾病方面有着悠久的使用历史。我们对评估雷公藤治疗特发性难治性肾病综合征(IRNS)有效性的随机对照试验(RCT)和半随机对照试验进行了荟萃分析。在阅读全文后,仅选择了三项符合我们纳入标准的RCT或半随机对照试验。我们的荟萃分析表明,雷公藤对IRNS的缓解具有有益作用。荟萃分析研究中没有显著的发表偏倚。然而,在得出确切结论之前,需要进行样本量更大且分别纳入轻度和重度组织病理学改变患者的研究,以评估雷公藤对IRNS患者的疗效。