Pasdaran Ardalan, Hassani Bahareh, Tavakoli Ali, Kozuharova Ekaterina, Hamedi Azadeh
Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz 7146864685, Iran.
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz 7146864685, Iran.
Life (Basel). 2023 Jul 19;13(7):1589. doi: 10.3390/life13071589.
The Latin word lupus, meaning wolf, was in the medical literature prior to the 1200s to describe skin lesions that devour flesh, and the resources available to physicians to help people were limited. The present text reviews the ethnobotanical and pharmacological aspects of medicinal plants and purified molecules from natural sources with efficacy against lupus conditions. Among these molecules are artemisinin and its derivatives, antroquinonol, baicalin, curcumin, emodin, mangiferin, salvianolic acid A, triptolide, the total glycosides of paeony (TGP), and other supplements such as fatty acids and vitamins. In addition, medicinal plants, herbal remedies, mushrooms, and fungi that have been investigated for their effects on different lupus conditions through clinical trials, in vivo, in vitro, or in silico studies are reviewed. A special emphasis was placed on clinical trials, active phytochemicals, and their mechanisms of action. This review can be helpful for researchers in designing new goal-oriented studies. It can also help practitioners gain insight into recent updates on supplements that might help patients suffering from lupus conditions.
拉丁词“lupus”意为狼，在13世纪之前的医学文献中用于描述侵蚀肉体的皮肤损伤，当时医生可用于帮助患者的资源有限。本文综述了药用植物以及天然来源的纯化分子在民族植物学和药理学方面对狼疮病症的疗效。这些分子包括青蒿素及其衍生物、antroquinonol、黄芩苷、姜黄素、大黄素、芒果苷、丹酚酸A、雷公藤内酯醇、芍药总苷（TGP）以及其他补充剂，如脂肪酸和维生素。此外，还综述了通过临床试验、体内、体外或计算机模拟研究调查过其对不同狼疮病症影响的药用植物、草药、蘑菇和真菌。特别强调了临床试验、活性植物化学物质及其作用机制。这篇综述有助于研究人员设计新的目标导向性研究。它还可以帮助从业者深入了解可能有助于狼疮患者的补充剂的最新情况。
