Okamura Yukiyasu, Maeda Atsuyuki, Matsunaga Kazuya, Kanemoto Hideyuki, Boku Narikazu, Furukawa Hiroyoshi, Sasaki Keiko, Uesaka Katsuhiko
Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, 1007 Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 411-8777, Japan.
J Hepatobiliary Pancreat Surg. 2009;16(4):575-8. doi: 10.1007/s00534-009-0051-4. Epub 2009 Mar 14.
Small-cell carcinoma occasionally occurs in the gastrointestinal tract, with rare reports of it in the biliary system. When it does occur in the biliary system, it is mainly within the gallbladder, and those arising in the extrahepatic bile duct are extremely rare with only seven reported cases to date. A 62-year-old man with this unusual condition is documented. The patient was preoperatively diagnosed as having small-cell carcinoma on the basis of a biopsy specimen and was treated with multidisciplinary management, which consisted of preoperative chemotherapy, a curative resection, adjuvant chemotherapy, and radiation therapy. The patient died 23 months after the initial diagnosis (20 months after surgery). To the best of our knowledge, the survival time of this case was the longest among reported cases, and multidisciplinary management might contribute to a prolonged survival.
小细胞癌偶尔发生于胃肠道，在胆道系统中的报道极为罕见。当它确实发生在胆道系统时，主要位于胆囊，而发生于肝外胆管的则极其罕见，迄今为止仅有7例报道。本文记录了一名患有这种罕见病症的62岁男性患者。该患者术前经活检标本诊断为小细胞癌，并接受了多学科综合治疗，包括术前化疗、根治性切除、辅助化疗和放疗。患者在初次诊断后23个月（手术后20个月）死亡。据我们所知，该病例的生存时间在已报道病例中是最长的，多学科综合治疗可能有助于延长生存期。
