使用氟掺杂手工制作传感器对吸烟者尿液离体液中六价铬进行诊断检测。
Diagnostic assay of chromium (VI) in the ex vivo fluid of the urine of a smoker using a fluorine-doped handmade sensor.
作者信息
Ly Suw Young, Kim Min Joon
机构信息
Biosensor Research Institute, Seoul National University of Technology, 172 gongreung 2-dong, Nowon-gu, Seoul, South Korea.
出版信息
J Clin Lab Anal. 2009;23(2):82-7. doi: 10.1002/jcla.20294.
Abstract
A voltammetric diagnosis of a chromium (VI) ion was investigated using a fluorine-doped graphite pencil electrode. Square wave (SW) stripping working conditions were attained at a high range of 0.051-0.45 mg L(-1) and a microrange of 0.05-0.4 microg L(-1) in a 0.1 M NH(4)H(2)PO(4) electrolyte solution, at a relative standard deviation of 1.68% (RSD, n=15), using 10.0 microg L(-1) Cr(VI). A fast experimental time was used only for the 120 sec SW accumulation time. An analytical detection-limit (DL) of 0.008 microg L(-1) was attained. DL appeared to be more sensitive than common voltammetric and spectrophotometric assays. The developed sensor was applied to tap water and the urine of a smoker. It was found that the methods can be applicable for in vivo fluid or medicinal diagnosis.
摘要
使用氟掺杂石墨铅笔电极对六价铬离子进行了伏安诊断。在0.1 M NH₄H₂PO₄电解质溶液中，采用方波（SW）溶出法，在0.051 - 0.45 mg L⁻¹的高浓度范围和0.05 - 0.4 μg L⁻¹的微浓度范围内，以10.0 μg L⁻¹的Cr(VI)为标准，相对标准偏差为1.68%（RSD，n = 15）。快速实验时间仅用于120秒的SW富集时间。获得了0.008 μg L⁻¹的分析检测限（DL）。DL似乎比普通伏安法和分光光度法更灵敏。所开发的传感器应用于自来水和吸烟者的尿液。结果发现该方法可用于体内液体或药物诊断。
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