胚胎发育与内环境稳定中的转化生长因子-β超家族信号传导

Tgf-beta superfamily signaling in embryonic development and homeostasis.

作者信息

Wu Mary Y, Hill Caroline S

机构信息

Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

出版信息

Dev Cell. 2009 Mar;16(3):329-43. doi: 10.1016/j.devcel.2009.02.012.

DOI:10.1016/j.devcel.2009.02.012

PMID:19289080

Abstract

TGF-beta superfamily signaling pathways emerged with the evolution of multicellular animals, suggesting that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms. In this review we begin by exploring some key developmental and disease processes requiring TGF-beta ligands to underscore the fundamental importance of these pathways before delving into the molecular mechanism of signal transduction, focusing on recent findings. Finally, we discuss how these ligands act as morphogens, how their activity and signaling range is regulated, and how they interact with other signaling pathways to achieve their specific and varied functional roles.

摘要

转化生长因子-β（TGF-β）超家族信号通路随着多细胞动物的进化而出现，这表明这些通路有助于这些生物体发育和体内平衡所需的多样性和复杂性增加。在本综述中，我们首先探讨一些需要TGF-β配体的关键发育和疾病过程，以强调这些通路的根本重要性，然后再深入研究信号转导的分子机制，重点关注最新发现。最后，我们讨论这些配体如何作为形态发生素发挥作用，它们的活性和信号范围如何调节，以及它们如何与其他信号通路相互作用以实现其特定和多样的功能作用。