Readinger Julie A, Mueller Kristen L, Venegas Ana M, Horai Reiko, Schwartzberg Pamela L
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Immunol Rev. 2009 Mar;228(1):93-114. doi: 10.1111/j.1600-065X.2008.00757.x.
The Tec (tyrosine kinase expressed in hepatocellular carcinoma) family of non-receptor tyrosine kinases consists of five members: Tec, Bruton's tyrosine kinase (Btk), inducible T-cell kinase (Itk), resting lymphocyte kinase (Rlk/Txk), and bone marrow-expressed kinase (Bmx/Etk). Although their functions are probably best understood in antigen receptor signaling, where they participate in the phosphorylation and regulation of phospholipase C-gamma (PLC-gamma), it is now appreciated that these kinases contribute to signaling from many receptors and that they participate in multiple downstream pathways, including regulation of the actin cytoskeleton. In T cells, three Tec kinases are expressed, Itk, Rlk/Txk, and Tec. Itk is expressed at highest amounts and plays the major role in regulating signaling from the T-cell receptor. Recent studies provide evidence that these kinases contribute to multiple aspects of T-cell biology and have unique roles in T-cell development that have revealed new insight into the regulation of conventional and innate T-cell development. We review new findings on the Tec kinases with a focus on their roles in T-cell development and mature T-cell differentiation.
非受体酪氨酸激酶的Tec（在肝细胞癌中表达的酪氨酸激酶）家族由五个成员组成：Tec、布鲁顿酪氨酸激酶（Btk）、诱导性T细胞激酶（Itk）、静息淋巴细胞激酶（Rlk/Txk）和骨髓表达激酶（Bmx/Etk）。尽管它们的功能可能在抗原受体信号传导中理解得最为透彻，在该过程中它们参与磷脂酶C-γ（PLC-γ）的磷酸化和调节，但现在人们认识到这些激酶有助于多种受体的信号传导，并且它们参与多个下游途径，包括肌动蛋白细胞骨架的调节。在T细胞中，表达三种Tec激酶，即Itk、Rlk/Txk和Tec。Itk表达量最高，在调节T细胞受体信号传导中起主要作用。最近的研究提供了证据，表明这些激酶对T细胞生物学的多个方面有贡献，并且在T细胞发育中具有独特作用，这为传统和固有T细胞发育的调节提供了新的见解。我们综述了关于Tec激酶的新发现，重点关注它们在T细胞发育和成熟T细胞分化中的作用。
