Khadem G M, Heble S, Kumar R, White C
Department of Medicine and Psychiatry, Taranaki Base Hospital, New Plymouth, New Zealand.
Intern Med J. 2009 Jan;39(1):54-6. doi: 10.1111/j.1445-5994.2008.01808.x.
We report the case of a 57-year-old woman who developed acute psychiatric symptoms, behavioural disturbances, insomnia and dystonia resembling a catatonic state. During the course of her illness she developed hypoventilation and required monitoring in the intensive care unit. Her serum and cerebrospinal fluid showed antibodies to the NR1/NR2 heteromers of the N-methyl-D-aspartate receptor (NMDAR). Anti-NMDAR encephalitis is a severe form of autoimmune encephalitis, which has only recently been described in the published work. Most patients improve with immunosuppressive treatment. Raising awareness of this rare but increasingly reported condition is important, as it is responsive to treatment and potentially reversible.
我们报告了一例57岁女性病例，该患者出现急性精神症状、行为障碍、失眠以及类似紧张症状态的肌张力障碍。在患病过程中，她出现了通气不足，需要在重症监护病房进行监测。她的血清和脑脊液显示出针对N-甲基-D-天冬氨酸受体（NMDAR）的NR1/NR2异聚体的抗体。抗NMDAR脑炎是自身免疫性脑炎的一种严重形式，直到最近才在已发表的研究中被描述。大多数患者通过免疫抑制治疗可得到改善。提高对这种罕见但报告日益增多的疾病的认识很重要，因为它对治疗有反应且可能可逆。
