Paul Aaron G, Ahmad Nazni W, Lee H L, Ariff Ashraff M, Saranum Masri, Naicker Amara S, Osman Zulkiflee
Department of Orthopaedic Surgery, Sarawak General Hospital, Sarawak, Malaysia.
Int Wound J. 2009 Feb;6(1):39-46. doi: 10.1111/j.1742-481X.2008.00564.x.
This is prospective case-control study of more than 18 months performed to assess the effectiveness of maggot debridement therapy (MDT) with the sterile larvae of Lucilia cuprina (a tropical blowfly maggot) for the treatment of diabetic foot ulcers. Literature thus far has only reported results with the temperate maggot, Lucilia sericata. This study documents outcome in diabetic foot wounds treated with maggot debridement versus those treated by conventional debridement alone. In this series of 29 patients treated with MDT, 14 wounds were healed, 11 were unhealed and 4 were classified under others. The control group treated by conventional debridement had 30 patients of which 18 wounds were healed, 11 unhealed and 1 classified under others. There was no significant difference in outcome between the two groups. The conclusion that can be made from this study is that MDT with L. cuprina is as effective as conventional debridement in the treatment of diabetic foot ulcers. It would be a feasible alternative to those at high risk for surgery or for those who refuse surgery.
这是一项为期18个月以上的前瞻性病例对照研究，旨在评估利用铜绿蝇（一种热带丽蝇蛆）的无菌幼虫进行蛆虫清创疗法（MDT）治疗糖尿病足溃疡的有效性。迄今为止的文献仅报道了温带地区的蛆虫，即丝光绿蝇的治疗结果。本研究记录了接受蛆虫清创治疗的糖尿病足伤口与仅接受传统清创治疗的伤口的治疗结果。在这组接受MDT治疗的29例患者中，14处伤口愈合，11处未愈合，4处归为其他情况。接受传统清创治疗的对照组有30例患者，其中18处伤口愈合，11处未愈合，1处归为其他情况。两组的治疗结果无显著差异。从本研究中可以得出的结论是，使用铜绿蝇进行MDT在治疗糖尿病足溃疡方面与传统清创一样有效。对于手术风险高的患者或拒绝手术的患者而言，这将是一种可行的替代方法。
