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导管原位癌向浸润性乳腺癌的转变：问题的另一面。

The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin.

作者信息

Schnitt Stuart J

出版信息

Breast Cancer Res. 2009;11(1):101. doi: 10.1186/bcr2228. Epub 2009 Feb 27.

DOI:10.1186/bcr2228
PMID:19291276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2687714/
Abstract

The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition from DCIS to invasive cancer is strongly dependent upon alterations in the microenvironment. The potential roles of myoepithelial cells and of stromal-epithelial interaction are of particular interest in this regard.

摘要

乳腺导管原位癌（DCIS）进展为浸润性乳腺癌的相关因素尚不清楚。许多关于该主题的研究聚焦于肿瘤上皮细胞中分子和基因改变的作用。然而，新出现的证据表明，从DCIS向浸润性癌的转变强烈依赖于微环境的改变。在这方面，肌上皮细胞以及基质-上皮相互作用的潜在作用尤其令人关注。

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本文引用的文献

1
Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: biologic and diagnostic implications.导管原位癌相关肌上皮细胞的表型改变：生物学及诊断意义
Am J Surg Pathol. 2009 Feb;33(2):227-32. doi: 10.1097/PAS.0b013e318180431d.
2
Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma.有证据表明，在乳腺导管癌进展过程中，细胞的分子变化先于形态学改变出现。
Breast Cancer Res. 2008;10(5):R87. doi: 10.1186/bcr2157. Epub 2008 Oct 17.
3
Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression.上皮和基质组织蛋白酶K及CXCL14在乳腺肿瘤进展中的表达
Clin Cancer Res. 2008 Sep 1;14(17):5357-67. doi: 10.1158/1078-0432.CCR-08-0732.
4
Do myoepithelial cells hold the key for breast tumor progression?肌上皮细胞是乳腺肿瘤进展的关键因素吗？
J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):231-47. doi: 10.1007/s10911-005-9584-6.
5
Mechanisms of disease: breast tumor pathogenesis and the role of the myoepithelial cell.疾病机制：乳腺肿瘤发病机制及肌上皮细胞的作用。
Nat Clin Pract Oncol. 2006 Mar;3(3):138-51. doi: 10.1038/ncponc0450.
6
Myoepithelial cells: good fences make good neighbors.肌上皮细胞：好篱笆造就好邻居。
Breast Cancer Res. 2005;7(5):190-7. doi: 10.1186/bcr1286. Epub 2005 Jul 12.
7
Distinct epigenetic changes in the stromal cells of breast cancers.乳腺癌基质细胞中不同的表观遗传变化。
Nat Genet. 2005 Aug;37(8):899-905. doi: 10.1038/ng1596. Epub 2005 Jul 10.
8
Tumour-stromal interactions in breast cancer: the role of stroma in tumourigenesis.乳腺癌中的肿瘤-基质相互作用：基质在肿瘤发生中的作用。
Tumour Biol. 2005 Jul-Aug;26(4):173-85. doi: 10.1159/000086950. Epub 2005 Jul 6.
9
Molecular characterization of the tumor microenvironment in breast cancer.乳腺癌肿瘤微环境的分子特征
Cancer Cell. 2004 Jul;6(1):17-32. doi: 10.1016/j.ccr.2004.06.010.
10
Gene expression profiles of human breast cancer progression.人类乳腺癌进展的基因表达谱
Proc Natl Acad Sci U S A. 2003 May 13;100(10):5974-9. doi: 10.1073/pnas.0931261100. Epub 2003 Apr 24.