产前压力与儿童热性惊厥风险：丹麦一项全国性纵向研究
Prenatal stress and risk of febrile seizures in children: a nationwide longitudinal study in Denmark.
作者信息
Li Jiong, Olsen Jørn, Obel Carsten, Christensen Jakob, Precht Dorthe Hansen, Vestergaard Mogens
机构信息
The Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, The University of Aarhus, Vennelyst Boulevard 6, 8000 Arhus C, Denmark.
出版信息
J Autism Dev Disord. 2009 Jul;39(7):1047-52. doi: 10.1007/s10803-009-0717-4. Epub 2009 Mar 17.
Abstract
We aimed to examine whether exposure to prenatal stress following maternal bereavement is associated with an increased risk of febrile seizures. In a longitudinal population-based cohort study, we followed 1,431,175 children born in Denmark. A total of 34,777 children were born to women who lost a close relative during pregnancy or within 1 year before the pregnancy and they were included in the exposed group. The exposed children had a risk of febrile seizures similar to that of the unexposed children (hazard ratio (HR) 1.00, 95% CI 0.94-1.06). The HRs did not differ according to the nature or timing of bereavement. Our data do not suggest any causal link between exposure to prenatal stress and febrile seizures in childhood.
摘要
我们旨在研究母亲丧亲后暴露于产前压力是否与热性惊厥风险增加有关。在一项基于人群的纵向队列研究中，我们追踪了丹麦出生的1,431,175名儿童。共有34,777名儿童的母亲在孕期或怀孕前1年内失去了近亲，这些儿童被纳入暴露组。暴露组儿童发生热性惊厥的风险与未暴露组儿童相似（风险比（HR）为1.00，95%置信区间为0.94 - 1.06）。风险比并未因丧亲的性质或时间而有所不同。我们的数据并未表明产前压力暴露与儿童热性惊厥之间存在任何因果关系。
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