Fife Douglas J, Fitzpatrick Richard E, Zachary Christopher B
Department of Dermatology, Northwestern University, Chicago, Illinois 60611, USA.
Lasers Surg Med. 2009 Mar;41(3):179-84. doi: 10.1002/lsm.20753.
Fractional ablative laser therapy is a new modality which will likely be widely used due to its efficacy and limited side-effect profile. It is critical to recognize, characterize, and report complications in order to acknowledge the limits of therapeutic efficacy and to improve the safety of these devices.
STUDY DESIGN/MATERIALS AND METHODS: The photographs, treatment parameters, and clinical files of four female patients aged 54-67 who had scarring or ectropion after fractional CO(2) laser resurfacing on the face or neck were carefully reviewed to search for any possible linking factors.
Patient 1 developed erosions and swelling of the right lower eyelid 2 days postoperatively, which developed into scarring and an ectropion. Patient 2 developed linear erosions and beefy red swelling on the right side of the neck which developed into a tender, band-like scar over 1-month. Patient 3 developed stinging and yellow exudate in multiple areas of the neck 3 days postoperatively. Cultures grew methicillin-resistant Staphylococcus aureus. Despite appropriate treatment, she developed multiple areas of irregular texture and linear streaking which developed into scars. Patient 4 developed an asymptomatic patchy, soft eschar with yellowish change on the left side of the neck. Azithromycin was started, however at 2-week follow-up she had fibrotic streaking which developed into horizontal scars and a vertical platysmal band. The treatment and final outcome of each patient are described.
Scarring after fractional CO(2) laser therapy may be due to overly aggressive treatments in sensitive areas (including excessive energy, density, or both), lack of technical finesse, associated infection, or idiopathic. Care should be taken when treating sensitive areas such as the eyelids, upper neck, and especially the lower neck and chest by using lower energy and density. Postoperative infections may lead to scarring and may be prevented by careful taking of history, vigilant postoperative monitoring and/or prophylactic antibiotics.
分次消融激光治疗是一种新的治疗方式,因其疗效显著且副作用有限,可能会被广泛应用。认识、描述并报告并发症对于了解治疗效果的局限性以及提高这些设备的安全性至关重要。
研究设计/材料与方法:仔细回顾了4例年龄在54 - 67岁之间的女性患者的照片、治疗参数及临床资料,这些患者在面部或颈部接受分次二氧化碳激光磨皮术后出现了瘢痕形成或睑外翻,以寻找任何可能的相关因素。
患者1术后2天右下眼睑出现糜烂和肿胀,随后发展为瘢痕形成和睑外翻。患者2颈部右侧出现线性糜烂和牛肉样红肿,1个月后发展为条索状瘢痕。患者3术后3天颈部多个区域出现刺痛和黄色渗出物。培养结果显示为耐甲氧西林金黄色葡萄球菌。尽管进行了适当治疗,她仍出现多个质地不规则和线性条纹区域,随后发展为瘢痕。患者4颈部左侧出现无症状的斑片状、柔软焦痂伴发黄改变。开始使用阿奇霉素治疗,然而在2周随访时她出现纤维化条纹,随后发展为水平瘢痕和垂直的颈阔肌带。描述了每位患者的治疗及最终结局。
分次二氧化碳激光治疗后瘢痕形成可能是由于在敏感区域治疗过度激进(包括能量过高、密度过大或两者兼有)、缺乏技术技巧、合并感染或特发性原因。在治疗敏感区域如眼睑、上颈部,尤其是下颈部和胸部时应谨慎,使用较低的能量和密度。术后感染可能导致瘢痕形成,通过仔细询问病史、术后密切监测和/或预防性使用抗生素可预防感染。