Clementi Alessandro, Cannarozzo Giovanni, Guarino Luca, Zappia Elena, Cassalia Fortunato, Alma Antonio, Sannino Mario, Longo Caterina, Nisticò Steven Paul
Department of Dermatology, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Department of Clinical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
J Clin Med. 2025 May 30;14(11):3867. doi: 10.3390/jcm14113867.
Ablative fractional CO laser is an established tool for dermatologic and aesthetic indications. Non-ablative wavelengths, such as 1540 and 1570 nm, are increasingly being combined with CO laser to optimise the results while reducing the recovery time. A narrative review of the literature was conducted, including ex vivo, in vivo, and in vitro studies, as well as human clinical trials that evaluated the efficacy, safety, and histological impact of dual-laser systems. Preclinical studies have shown that sequential application of fractional CO followed by 1540/1570 nm expands the thermal coagulation zone without increasing the ablation depth. At the histological level, the dual protocol promotes collagen remodelling with greater thermal precision. On a clinical level, a combined treatment has shown efficacy in improving scars, striae distensae, skin laxity, and wrinkles, with reduced recovery times compared to CO monotherapy. Preliminary data also suggest potential benefits in inflammatory conditions such as hidradenitis suppurativa. The sequential CO + 1540/1570 nm combination represents an effective and well-tolerated approach in regenerative dermatology. Current evidence supports its use as a versatile, safe, and reproducible technique for skin rejuvenation and scar modulation; however, further comparative studies are needed to standardise protocols.
剥脱性分数二氧化碳激光是一种用于皮肤科和美容适应症的成熟工具。非剥脱性波长,如1540和1570纳米,越来越多地与二氧化碳激光联合使用,以优化效果,同时缩短恢复时间。我们对文献进行了叙述性综述,包括离体、体内和体外研究,以及评估双激光系统疗效、安全性和组织学影响的人体临床试验。临床前研究表明,先应用分数二氧化碳激光,再应用1540/1570纳米激光,可扩大热凝固区,而不增加消融深度。在组织学层面,双激光方案能以更高的热精度促进胶原蛋白重塑。在临床层面,联合治疗在改善瘢痕、膨胀纹、皮肤松弛和皱纹方面已显示出疗效,与二氧化碳激光单一疗法相比,恢复时间更短。初步数据还表明,该联合治疗在化脓性汗腺炎等炎症性疾病中可能具有益处。二氧化碳激光+1540/1570纳米激光的序贯联合治疗是再生皮肤科一种有效且耐受性良好的方法。目前的证据支持将其作为一种通用、安全且可重复的皮肤年轻化和瘢痕调节技术使用;然而,需要进一步的比较研究来规范治疗方案。