更昔洛韦与齐多夫定协同细胞毒性的三维分析
Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine.
作者信息
Prichard M N, Prichard L E, Baguley W A, Nassiri M R, Shipman C
机构信息
Department of Microbiology and Immunology, School of Medicine, Ann Arbor, Michigan.
出版信息
Antimicrob Agents Chemother. 1991 Jun;35(6):1060-5. doi: 10.1128/AAC.35.6.1060.
Abstract
The combined cytotoxicity of zidovudine and ganciclovir in three cell lines of human origin was examined. The data were generated by a new rapid cell proliferation assay and a more sensitive plating efficiency assay. A three-dimensional analytical approach was used to evaluate the drug-drug interactions, and the results were compared with those obtained by two conventional methods of analysis. Synergistic cytotoxicity was observed in all cell lines examined and by both assays. Moreover, this synergistic cytotoxicity was statistically significant at physiologically relevant concentrations. It is not known whether these drug-drug interactions manifest themselves in vivo as granulocytopenia or other untoward side effects. These results, however, indicate that further investigation is warranted and that the coadministration of zidovudine and ganciclovir may be contraindicated.
摘要
研究了齐多夫定和更昔洛韦对三种人源细胞系的联合细胞毒性。数据通过一种新的快速细胞增殖测定法和一种更灵敏的平板接种效率测定法得出。采用三维分析方法评估药物相互作用，并将结果与通过两种传统分析方法获得的结果进行比较。在所检测的所有细胞系中以及两种测定法中均观察到协同细胞毒性。此外，在生理相关浓度下，这种协同细胞毒性具有统计学意义。尚不清楚这些药物相互作用在体内是否表现为粒细胞减少或其他不良副作用。然而，这些结果表明有必要进行进一步研究，并且齐多夫定和更昔洛韦的联合给药可能是禁忌的。
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