BW759U的三磷酸盐对细胞α-DNA聚合酶和单纯疱疹病毒诱导的DNA聚合酶的抑制作用。
Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U.
作者信息
St Clair M H, Miller W H, Miller R L, Lambe C U, Furman P A
出版信息
Antimicrob Agents Chemother. 1984 Feb;25(2):191-4. doi: 10.1128/AAC.25.2.191.
Abstract
The triphosphate form of the acyclovir analog BW759U (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) inhibited the DNA polymerases (EC 2.7.7.7) from several strains of herpes simplex virus type 1. Two acyclovir triphosphate-resistant DNA polymerases were as sensitive to BW759U-triphosphate as were the DNA polymerases induced by wild-type viruses (Ki = 0.05 to 0.1 microM). The Ki value for cellular alpha DNA polymerase was 35- to 50-fold greater than those for the DNA polymerases induced by the various herpes simplex virus strains investigated. Incubation of Vero cells infected by the KOS strain of herpes simplex virus type 1 with the acyclovir analog resulted in the formation of substantial quantities of (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) triphosphate.
摘要
无环鸟苷类似物BW759U（9 - [[2 - 羟基 - 1 -（羟甲基）乙氧基]甲基]鸟嘌呤）的三磷酸形式抑制了来自几株单纯疱疹病毒1型的DNA聚合酶（EC 2.7.7.7）。两种对无环鸟苷三磷酸耐药的DNA聚合酶对BW759U - 三磷酸的敏感性与野生型病毒诱导的DNA聚合酶相同（Ki = 0.05至0.1 microM）。细胞α - DNA聚合酶的Ki值比所研究的各种单纯疱疹病毒株诱导的DNA聚合酶的Ki值大35至50倍。用无环鸟苷类似物孵育被单纯疱疹病毒1型KOS株感染的Vero细胞，导致大量（9 - [[2 - 羟基 - 1 -（羟甲基）乙氧基]甲基]鸟嘌呤）三磷酸的形成。
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