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2
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Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells.新型抗疱疹病毒化合物9-（1,3-二羟基-2-丙氧甲基）鸟嘌呤对单纯疱疹病毒感染细胞中大分子合成的影响。
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本文引用的文献

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Computer programmes for processing enzyme kinetic data.用于处理酶动力学数据的计算机程序。
Nature. 1963 May 4;198:463-5. doi: 10.1038/198463a0.
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Statistical estimations in enzyme kinetics.酶动力学中的统计估计
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Statistical methods to distinguish competitive, noncompetitive, and uncompetitive enzyme inhibitors.区分竞争性、非竞争性和反竞争性酶抑制剂的统计方法。
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4
Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir.阿昔洛韦三磷酸盐对细胞α和病毒诱导的脱氧核糖核酸聚合酶的抑制作用。
Antimicrob Agents Chemother. 1980 Nov;18(5):741-5. doi: 10.1128/AAC.18.5.741.
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Phosphorylation of acyclovir diphosphate by cellular enzymes.阿昔洛韦二磷酸被细胞酶磷酸化。
Biochem Pharmacol. 1982 Dec 1;31(23):3879-84. doi: 10.1016/0006-2952(82)90305-7.
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9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.9 -（[2 - 羟基 - 1 -（羟甲基）乙氧基]甲基）鸟嘌呤：一种疱疹病毒组复制的选择性抑制剂。
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Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.9-[(1,3-二羟基-2-丙氧基)甲基]鸟嘌呤对疱疹病毒的独特体外活性谱及其对1型单纯疱疹病毒的作用方式
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8
A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2.一种新的核苷类似物，9-[[2-羟基-1-(羟甲基)乙氧基]甲基]鸟嘌呤，在体外对1型和2型单纯疱疹病毒具有高度活性。
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9
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.1型单纯疱疹病毒的阿昔洛韦耐药突变体表现出DNA聚合酶改变或阿昔洛韦磷酸化活性降低。
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10
Kinetics and intermediates in the intracellular synthesis of bacteriophage T4 deoxyribonucleic acid.噬菌体T4脱氧核糖核酸细胞内合成的动力学及中间产物
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BW759U的三磷酸盐对细胞α-DNA聚合酶和单纯疱疹病毒诱导的DNA聚合酶的抑制作用。

Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U.

作者信息

St Clair M H, Miller W H, Miller R L, Lambe C U, Furman P A

出版信息

Antimicrob Agents Chemother. 1984 Feb;25(2):191-4. doi: 10.1128/AAC.25.2.191.

DOI:10.1128/AAC.25.2.191
PMID:6324666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185472/
Abstract

The triphosphate form of the acyclovir analog BW759U (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) inhibited the DNA polymerases (EC 2.7.7.7) from several strains of herpes simplex virus type 1. Two acyclovir triphosphate-resistant DNA polymerases were as sensitive to BW759U-triphosphate as were the DNA polymerases induced by wild-type viruses (Ki = 0.05 to 0.1 microM). The Ki value for cellular alpha DNA polymerase was 35- to 50-fold greater than those for the DNA polymerases induced by the various herpes simplex virus strains investigated. Incubation of Vero cells infected by the KOS strain of herpes simplex virus type 1 with the acyclovir analog resulted in the formation of substantial quantities of (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) triphosphate.

摘要

无环鸟苷类似物BW759U（9 - [[2 - 羟基 - 1 -（羟甲基）乙氧基]甲基]鸟嘌呤）的三磷酸形式抑制了来自几株单纯疱疹病毒1型的DNA聚合酶（EC 2.7.7.7）。两种对无环鸟苷三磷酸耐药的DNA聚合酶对BW759U - 三磷酸的敏感性与野生型病毒诱导的DNA聚合酶相同（Ki = 0.05至0.1 microM）。细胞α - DNA聚合酶的Ki值比所研究的各种单纯疱疹病毒株诱导的DNA聚合酶的Ki值大35至50倍。用无环鸟苷类似物孵育被单纯疱疹病毒1型KOS株感染的Vero细胞，导致大量（9 - [[2 - 羟基 - 1 -（羟甲基）乙氧基]甲基]鸟嘌呤）三磷酸的形成。