Geraets Liesbeth, Haegens Astrid, Brauers Karen, Haydock Jane A, Vernooy Juanita H J, Wouters Emiel F M, Bast Aalt, Hageman Geja J
Department of Pharmacology and Toxicology, Maastricht University Maastricht, The Netherlands.
Biochem Biophys Res Commun. 2009 May 8;382(3):598-603. doi: 10.1016/j.bbrc.2009.03.071. Epub 2009 Mar 16.
In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.
在本研究中，在脂多糖诱导的急性肺部炎症小鼠模型中评估了黄酮、非瑟酮和三羟黄酮的抗炎作用。黄酮类化合物非瑟酮显著降低了肺髓过氧化物酶水平以及炎症介质如白细胞介素-6、肿瘤坏死因子-α、白细胞介素-1β、巨噬细胞炎性蛋白-1α和巨噬细胞炎性蛋白-2的基因表达。非瑟酮还显著降低了脂多糖诱导的血红素加氧酶-1和超氧化物歧化酶2的基因转录。总体而言，与黄酮或三羟黄酮以及抗炎糖皮质激素地塞米松的观察效果相比，非瑟酮在该体内模型中的抗炎作用更为显著。本研究结果表明，非瑟酮等黄酮类化合物可能是治疗肺部炎症性疾病的潜在药物或营养保健品候选物。
