Septembre-Malaterre Axelle, Boumendjel Ahcène, Seteyen Anne-Laure Sandenon, Boina Chailas, Gasque Philippe, Guiraud Pascale, Sélambarom Jimmy
Université de La Réunion, Unité de recherche Etudes Pharmaco-Immunologie (EPI), CHU La Réunion site Félix Guyon, Allée des Topazes, CS11021, 97400 Saint Denis de La Réunion, France.
Laboratoire d'immunologie clinique et expérimentale de la zone de l'océan indien (LICE-OI) CHU La Réunion site Félix Guyon, Allée des Topazes, CS11021, 97400 Saint Denis de La Réunion, France.
Phytomed Plus. 2022 Feb;2(1):100220. doi: 10.1016/j.phyplu.2022.100220. Epub 2022 Jan 15.
Polyphenols and particularly flavonoids are of constant interest to the scientific community. Flavonoids are investigated for their biological and pharmacological purposes, notably as antioxidant, anticancer, antiviral and for their anti-inflammatory activities. Certainly, one of the best-known flavonols recognized for its therapeutic and preventive properties, is quercetin. Despite its biological interest, quercetin suffer from some drawbacks, mainly related to its bioavailability. Hence, its synthetic or biosynthetic derivatives have been the subject of intensive research. The health-promoting biological activities of flavonols and derivatives mainly arise from their capacity to disrupt the host-pathogen interactions and/or to regulate host cellular functions including oxidative processes and immunological responses. In the age of coronavirus pandemic, the anti-inflammatory and antiviral potential of flavonols should be put forward to explore these substances for decreasing the viral load and inflammatory storm caused by the infection.
The present review will decipher and discuss the antioxidant, anti-inflammatory and antiviral capacities of major flavonol with a focus on the molecular basis and structure-activity relationships.
Current study used a combination of quercetin derivatives, pathway, antioxidant, anti-inflammatory, antiviral activities as keywords to retrieve the literature. This study critically reviewed the current literature and presented the ability of natural analogs of quercetin having superior antioxidant, anti-inflammatory and antiviral effects than the original molecule.
This review allowed the identification of relevant key structure-activity relationship elements and highlight approaches on the mechanisms governing the antioxidant, antiviral and anti-inflammatory activities.
Through a critical analysis of the literature, flavonols and more precisely quercetin derivatives reviewed and found to act simultaneously on inflammation, virus and oxidative stress, three key factors that may lead to life threatening diseases.
多酚类物质，尤其是黄酮类化合物一直是科学界关注的焦点。黄酮类化合物因其生物学和药理学特性而受到研究，特别是作为抗氧化剂、抗癌剂、抗病毒剂以及具有抗炎活性。当然，槲皮素是最著名的具有治疗和预防特性的黄酮醇之一。尽管其具有生物学意义，但槲皮素存在一些缺点，主要与其生物利用度有关。因此，其合成或生物合成衍生物一直是深入研究的对象。黄酮醇及其衍生物的健康促进生物活性主要源于它们破坏宿主 - 病原体相互作用和/或调节宿主细胞功能（包括氧化过程和免疫反应）的能力。在冠状病毒大流行的时代，应提出黄酮醇的抗炎和抗病毒潜力，以探索这些物质来降低感染引起的病毒载量和炎症风暴。
本综述将解读并讨论主要黄酮醇的抗氧化、抗炎和抗病毒能力，重点关注分子基础和构效关系。
本研究使用槲皮素衍生物、途径、抗氧化、抗炎、抗病毒活性等组合关键词检索文献。本研究对当前文献进行了批判性综述，并展示了槲皮素天然类似物比原始分子具有更强抗氧化、抗炎和抗病毒作用的能力。
本综述确定了相关的关键构效关系要素，并突出了控制抗氧化、抗病毒和抗炎活性机制的方法。
通过对文献的批判性分析，黄酮醇，更确切地说是槲皮素衍生物，经综述发现可同时作用于炎症、病毒和氧化应激这三个可能导致危及生命疾病的关键因素。
