司美格鲁肽不与蛋白质结合。

Xeomin is free from complexing proteins.

作者信息

Frevert Jürgen

机构信息

Merz Pharmaceuticals GmbH, Hermannswerder Haus 15, 14473 Potsdam, Germany.

出版信息

Toxicon. 2009 Oct;54(5):697-701. doi: 10.1016/j.toxicon.2009.03.010. Epub 2009 Mar 16.

DOI:10.1016/j.toxicon.2009.03.010

PMID:19292989

Abstract

In contrast to the other botulinum toxin products Xeomin only contains the 150kD neurotoxin without complexing proteins which have no therapeutic function and don't influence the diffusion of the neurotoxin. In large clinical Phase III studies (blepharospasm and cervical dystonia) Xeomin showed the same efficacy and profile of adverse events as Botox. Whereas competing product must be stored refrigerated, Xeomin is stable for 3years at room temperature.

摘要

与其他肉毒杆菌毒素产品不同，Xeomin仅含有150kD神经毒素，没有无治疗功能且不影响神经毒素扩散的复合蛋白。在大型临床III期研究（眼睑痉挛和颈部肌张力障碍）中，Xeomin显示出与保妥适相同的疗效和不良事件特征。与竞争产品必须冷藏保存不同，Xeomin在室温下可稳定保存3年。