The yin and yang of MeCP2 phosphorylation.
作者信息
Chao Hsiao-Tuan, Zoghbi Huda Y
机构信息
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4577-8. doi: 10.1073/pnas.0901518106. Epub 2009 Mar 17.
Abstract
摘要
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Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology.MeCP2 缺陷型神经胶质细胞对神经元树突形态的非细胞自主影响。
Nat Neurosci. 2009 Mar;12(3):311-7. doi: 10.1038/nn.2275. Epub 2009 Feb 22.
2
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.丝氨酸80位点的MeCP2磷酸化调控其与染色质的结合及神经功能。
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3
Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS.NECTIN样1细胞粘附分子的破坏导致中枢神经系统轴突髓鞘形成延迟。
J Neurosci. 2008 Nov 26;28(48):12815-9. doi: 10.1523/JNEUROSCI.2665-08.2008.
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Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.在表达Sim1的神经元中删除Mecp2揭示了MeCP2在进食行为、攻击行为和应激反应中的关键作用。
Neuron. 2008 Sep 25;59(6):947-58. doi: 10.1016/j.neuron.2008.07.030.
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MeCP2, a key contributor to neurological disease, activates and represses transcription.甲基化CpG结合蛋白2（MeCP2）是神经疾病的关键促成因素，可激活和抑制转录。
Science. 2008 May 30;320(5880):1224-9. doi: 10.1126/science.1153252.
6
A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome.甲基-CpG结合蛋白2的功能部分缺失等位基因预示着一种人类神经发育综合征。
Hum Mol Genet. 2008 Jun 15;17(12):1718-27. doi: 10.1093/hmg/ddn062. Epub 2008 Mar 4.
7
MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number.甲基化CpG结合蛋白2通过调节谷氨酸能突触数量来控制兴奋性突触强度。
Neuron. 2007 Oct 4;56(1):58-65. doi: 10.1016/j.neuron.2007.08.018.
8
Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males.在神经发育迟缓男性中，由于基因组重复导致MECP2基因拷贝数增加。
Genet Med. 2006 Dec;8(12):784-92. doi: 10.1097/01.gim.0000250502.28516.3c.
9
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.MeCP2在大脑中的特异性磷酸化调节活性依赖的Bdnf转录、树突生长和棘突成熟。
Neuron. 2006 Oct 19;52(2):255-69. doi: 10.1016/j.neuron.2006.09.037.
10
Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males.MECP2区域重复是男性严重智力迟钝和进行性神经症状的常见原因。
Am J Hum Genet. 2005 Sep;77(3):442-53. doi: 10.1086/444549. Epub 2005 Jul 29.
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