Yang C-H, Huang K-S, Lin Y-S, Lu K, Tzeng C-C, Wang E-C, Lin C-H, Hsu W-Y, Chang J-Y
Dept. of Biological Science & Technology, I-Shou University, Taiwan.
Lab Chip. 2009 Apr 7;9(7):961-5. doi: 10.1039/b814952f. Epub 2008 Dec 19.
This paper demonstrates a proof-of-concept approach for encapsulating the anticancer drug tamoxifen, Fe3O4 nanoparticles (NPs) and CdTe quantum dots (QDs) into size-controlled polycaprolactone (PCL) microcapsules utilizing microfluidic emulsification, which combined magnetic targeting, fluorescence imaging and drug controlled release properties into one drug delivery system. Cross-linking the composite PCL microcapsules with poly(vinyl alcohol) (PVA) tailored their size, morphology, optical and magnetic properties and drug release behaviors. The flow conditions of the two immiscible solutions were adjusted in order to successfully generate various sizes of polymer droplets. The result showed superparamagnetic and fluorescent properties, and was used as a controlled drug release vehicle. The composite magnetic and fluorescent PCL microcapsules are potential candidates for a smart drug delivery system.
本文展示了一种概念验证方法，即利用微流控乳化技术将抗癌药物他莫昔芬、四氧化三铁纳米颗粒（NPs）和碲化镉量子点（QDs）封装到尺寸可控的聚己内酯（PCL）微胶囊中，该方法将磁靶向、荧光成像和药物控释特性整合到一个药物递送系统中。用聚乙烯醇（PVA）交联复合PCL微胶囊，可调整其尺寸、形态、光学和磁性特性以及药物释放行为。调节两种不混溶溶液的流动条件，以成功生成各种尺寸的聚合物液滴。结果显示出超顺磁性和荧光特性，并用作控释药物载体。复合磁性和荧光PCL微胶囊是智能药物递送系统的潜在候选者。
