Zhang Hua, Chen YueQin
Key Laboratory of Genetic Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, Sun Yan-Sen University, Guangzhou, 510275, China.
Sci China C Life Sci. 2009 Mar;52(3):224-31. doi: 10.1007/s11427-009-0036-1. Epub 2009 Mar 18.
Recent studies have shown that microRNAs(miRNAs) play an important role in cell differentiation, growth, and death, including the functional study of miRNAs in tumorigenesis. To date, miRNA expression profiles in many types of cancers have been identified and miRNA expression signatures associated with types and cytogenetics of leukemia have also been reported. Increasing evidence has shown that miRNAs could function as either tumor suppressors or oncogenes in cancers such as leukemia, while other miRNAs might be benefitcial for diagnosis and prognosis, predicted to be newly developed biomarkers. In this review, we summarize the recent progress about miRNAs in leukemia and present a miRNA-mediated network involved in differentiation, proliferation and apoptosis predicted to be the roles of miRNAs in the pathogenesis of leukemia.
最近的研究表明，微小RNA（miRNA）在细胞分化、生长和死亡中发挥着重要作用，包括miRNA在肿瘤发生中的功能研究。迄今为止，已经确定了多种癌症中的miRNA表达谱，并且也报道了与白血病类型和细胞遗传学相关的miRNA表达特征。越来越多的证据表明，miRNA在白血病等癌症中既可以作为肿瘤抑制因子发挥作用，也可以作为癌基因发挥作用，而其他miRNA可能对诊断和预后有益，有望成为新开发的生物标志物。在这篇综述中，我们总结了miRNA在白血病方面的最新进展，并提出了一个miRNA介导的网络，该网络涉及分化、增殖和凋亡，预计这是miRNA在白血病发病机制中的作用。
