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Diagnosis of hepatocellular carcinoma.肝细胞癌的诊断
World J Gastroenterol. 2009 Mar 21;15(11):1301-14. doi: 10.3748/wjg.15.1301.
2
Evaluation of squamous cell carcinoma antigen-immunoglobulin M complex (SCCA-IGM) and alpha-L-fucosidase (AFU) as novel diagnostic biomarkers for hepatocellular carcinoma.评估鳞状细胞癌抗原-免疫球蛋白M复合物（SCCA-IGM）和α-L-岩藻糖苷酶（AFU）作为肝细胞癌新型诊断生物标志物的价值。
Tumour Biol. 2014 Nov;35(11):11559-64. doi: 10.1007/s13277-014-2467-y. Epub 2014 Aug 17.
3
Screening for hepatocellular carcinoma.肝细胞癌筛查
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VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma.血管性血友病因子/解整合素金属蛋白酶 13 比值作为肝细胞癌早期检测的潜在生物标志物。
BMC Gastroenterol. 2019 Oct 21;19(1):167. doi: 10.1186/s12876-019-1082-1.
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Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma.乙型肝炎病毒相关肝细胞癌的循环预测性和诊断性生物标志物
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Clinical biomarkers in hepatocellular carcinoma (HCC).肝细胞癌（HCC）中的临床生物标志物
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Biomarkers for the early diagnosis of hepatocellular carcinoma.肝细胞癌早期诊断的生物标志物。
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Diagnostic and prognostic value of alpha-fetoprotein, des-γ-carboxy prothrombin and squamous cell carcinoma antigen immunoglobulin M complexes in hepatocellular carcinoma.甲胎蛋白、脱 γ-羧基凝血酶原与鳞状细胞癌相关抗原免疫球蛋白 M 复合物在原发性肝癌中的诊断及预后价值。
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Evaluation of prothrombin induced by vitamin K absence, macrophage migration inhibitory factor and Golgi protein-73 versus alpha fetoprotein for hepatocellular carcinoma diagnosis and surveillance.维生素K缺乏诱导的凝血酶原、巨噬细胞移动抑制因子和高尔基体蛋白73与甲胎蛋白用于肝细胞癌诊断和监测的评估
Scand J Clin Lab Invest. 2017 May;77(3):175-183. doi: 10.1080/00365513.2017.1286684. Epub 2017 Feb 24.

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Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma.基于超声造影参数构建列线图模型以预测肝细胞癌病理分化程度
Front Oncol. 2025 Jan 27;15:1519703. doi: 10.3389/fonc.2025.1519703. eCollection 2025.
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Diagnostic Value of Circulating microRNAs for Hepatocellular Carcinoma: Results of a Meta-analysis and Validation.循环微小RNA对肝细胞癌的诊断价值：一项荟萃分析及验证结果
Biochem Genet. 2025 Jan 3. doi: 10.1007/s10528-024-11001-2.
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Association of Serum Levels and Immunohistochemical Labelling of Des-Gamma-Carboxy-Prothrombin in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.肝细胞癌肝移植患者血清去γ-羧基凝血酶原水平与免疫组化标记的相关性
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Serum antibody screening using glycan arrays.糖芯片血清抗体筛查。
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The prognostic significance of inflammation-immunity-nutrition score on postoperative survival and recurrence in hepatocellular carcinoma patients.炎症-免疫-营养评分对肝细胞癌患者术后生存及复发的预后意义
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Platelets' RNA as biomarker trove for differentiation of early-stage hepatocellular carcinoma from underlying cirrhotic nodules.血小板 RNA 作为生物标志物宝库，可用于区分早期肝细胞癌与潜在的肝硬化结节。
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Systemic immune-inflammation index predicts prognosis of sequential therapy with sorafenib and regorafenib in hepatocellular carcinoma.系统免疫炎症指数预测索拉非尼序贯regorafenib 治疗肝细胞癌的预后。
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Optimizing the Combination of Immunotherapy and Trans-Arterial Locoregional Therapy for Stages B and C Hepatocellular Cancer.优化免疫治疗与经动脉局部区域治疗联合用于 B 期和 C 期肝细胞癌。
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本文引用的文献

1
Needle tract implantation after percutaneous interventional procedures in hepatocellular carcinomas: lessons learned from a 10-year experience.肝细胞癌经皮介入治疗后针道种植：十年经验总结
Korean J Radiol. 2008 May-Jun;9(3):268-74. doi: 10.3348/kjr.2008.9.3.268.
2
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.磷脂酰肌醇蛋白聚糖-3介导的肿瘤发生涉及胰岛素样生长因子信号通路。
Carcinogenesis. 2008 Jul;29(7):1319-26. doi: 10.1093/carcin/bgn091. Epub 2008 Apr 15.
3
Preoperative predictors of vascular invasion in hepatocellular carcinoma.肝细胞癌血管侵犯的术前预测因素
Eur J Surg Oncol. 2008 Aug;34(8):900-905. doi: 10.1016/j.ejso.2008.01.031. Epub 2008 Mar 14.
4
Diagnosis of hepatocellular carcinoma.肝细胞癌的诊断。
HPB (Oxford). 2005;7(1):26-34. doi: 10.1080/13651820410024049.
5
Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) - update 2008.超声造影（CEUS）指南及临床实践建议 - 2008年更新版
Ultraschall Med. 2008 Feb;29(1):28-44. doi: 10.1055/s-2007-963785.
6
Utility of glypican-3 in differentiating hepatocellular carcinoma from other primary and metastatic lesions in FNA of the liver: an immunocytochemical study.Glypican-3在肝脏细针穿刺抽吸活检中鉴别肝细胞癌与其他原发性及转移性病变的效用：一项免疫细胞化学研究
Mod Pathol. 2008 May;21(5):626-31. doi: 10.1038/modpathol.2008.26. Epub 2008 Feb 8.
7
Radiological diagnosis of hepatocellular carcinoma.肝细胞癌的放射学诊断。
Liver Int. 2008 Feb;28(2):189-99. doi: 10.1111/j.1478-3231.2007.01655.x.
8
Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease.肝细胞癌和慢性肝病中的血清蛋白质组学与生物标志物
Clin Cancer Res. 2008 Jan 15;14(2):470-7. doi: 10.1158/1078-0432.CCR-07-0586.
9
PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection.异常凝血酶原是手术切除后复发性肝细胞癌的一种有用的肿瘤标志物。
Oncology. 2007;72 Suppl 1:52-7. doi: 10.1159/000111707. Epub 2007 Dec 13.
10
Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis: a histopathological study of surgically resected hepatocellular carcinoma.豆凝集素反应性甲胎蛋白和维生素K缺乏诱导蛋白II是预后不良的潜在指标：手术切除肝细胞癌的组织病理学研究
J Gastroenterol. 2007 Dec;42(12):962-8. doi: 10.1007/s00535-007-2117-x. Epub 2007 Dec 25.

肝细胞癌的诊断

Diagnosis of hepatocellular carcinoma.

作者信息

Gomaa Asmaa I, Khan Shahid A, Leen Edward L S, Waked Imam, Taylor-Robinson Simon D

机构信息

Department of Hepatology and Gastroenterology, Division of Medicine, Imperial College London, St Mary's Hospital Campus, South Wharf Road, London W2 1NY, United Kingdom.

出版信息

World J Gastroenterol. 2009 Mar 21;15(11):1301-14. doi: 10.3748/wjg.15.1301.

DOI:10.3748/wjg.15.1301
PMID:19294759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2658831/
Abstract

Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, particularly in parts of the developing world, and is increasing in incidence. This article reviews the current modalities employed for the diagnosis of HCC, including serum markers, radiological techniques and histological evaluation, and summarises international guidelines for the diagnostic approach to HCC.

摘要

肝细胞癌（HCC）是全球最常见的癌症之一，在发展中世界的部分地区尤为如此，且发病率正在上升。本文综述了目前用于诊断HCC的方法，包括血清标志物、放射学技术和组织学评估，并总结了HCC诊断方法的国际指南。