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临床分离的脆柄革盖菌对九种抗真菌药物的体外活性研究。

In vitro activity of nine antifungal agents against clinical isolates of Aspergillus calidoustus.

机构信息

Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

出版信息

Med Mycol. 2010 Feb;48(1):97-102. doi: 10.3109/13693780902803040.

Abstract

This study analyzes Aspergillus isolates from the Spanish National Centre for Microbiology collection, which were identified morphologically as members of Aspergillus section Usti. Strains were identified through the analysis of the Internal Transcribed Spacer regions and partial beta tubulin gene sequences. One Aspergillus pseudodeflectus isolate and eight Aspergillus calidoustus isolates were detected in this panel of clinical strains. Terbinafine and the echinocandins micafungin and anidulafungin, were the drugs most active against these species.

摘要

本研究分析了来自西班牙国家微生物学中心收藏的曲霉属分离株,这些分离株在形态上被鉴定为 Usti 节的成员。通过对内转录间隔区和部分β微管蛋白基因序列的分析来鉴定菌株。在这组临床菌株中检测到一个拟青霉和八个卡利多曲霉的分离株。特比萘芬和棘白菌素类药物米卡芬净和阿尼芬净对这些物种最具活性。

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