Yu Jun, Buslig Béla S, Haun Carl, Cancalon Paul
R & D Center, Damin International Group, Zhangzhou, Fujian, China.
Nat Prod Res. 2009;23(5):498-506. doi: 10.1080/14786410802449936.
Grapefruit (Citrus paradisi Macf.) furanocoumarins and related compounds have been shown to interact with the enterocyte cytochrome P450, CYP3A4, and as a result they affect the bioavailibility of certain drugs. Only a few grapefruit furanocoumarins have been identified so far. In this study, grapefruit juice retentate, rich in furanocoumarins, was extracted and then separated by flash chromatography for the examination of new compounds. Finally, nine new furanocoumarins were detected in different fractions according to their UV spectra and mass spectrometric properties by LC-MS (liquid chromatography mass spectrometry) and tentatively designated as FC 338, FC 420, FC 524, FC 530, FC 540, FC 546, FC 552, FC 570 and FC 614.
葡萄柚（Citrus paradisi Macf.）中的呋喃香豆素及相关化合物已被证明可与肠细胞色素P450、CYP3A4相互作用，因此会影响某些药物的生物利用度。到目前为止，仅鉴定出少数几种葡萄柚呋喃香豆素。在本研究中，提取了富含呋喃香豆素的葡萄柚汁截留物，然后通过快速色谱法进行分离，以检测新化合物。最后，根据液相色谱-质谱联用（LC-MS）的紫外光谱和质谱特性，在不同馏分中检测到9种新的呋喃香豆素，并暂定命名为FC 338、FC 420、FC 524、FC 530、FC 540、FC 546、FC 552、FC 570和FC 614。
