Hoshino Yu, Urakami Takeo, Kodama Takashi, Koide Hiroyuki, Oku Naoto, Okahata Yoshio, Shea Kenneth J
Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Small. 2009 Jul;5(13):1562-8. doi: 10.1002/smll.200900186.
Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.
制备了能够结合并中和生物大分子毒素的设计型聚合物纳米颗粒（NPs）。由功能单体组合合成了一系列共聚物NPs。分别分析了这些NPs的结合能力和亲和力。具有优化组成的NPs即使在复杂的生物环境中也能够中和毒素。预计这一策略将成为设计抗体合成替代物的起点。
