Ferrell L D, Beckstead J H
Department of Pathology, School of Medicine, University of California, San Francisco 94143-0506.
Arch Pathol Lab Med. 1991 Sep;115(9):956-8.
A case of adenocarcinoma with significant Paneth cell differentiation arising in a villoglandular polyp at the ampulla of Vater is presented. Paneth-like cells, containing distinct fuchsinophilic granules, were a prominent component of the nonglandular invasive adenocarcinoma and were also seen in the associated adenomatous polyp. Lysozyme, trichrome, and periodic acid-Schiff digest stains, and electron microscopy confirmed that the granules were lysosomal in nature. This case confirms that cells with Paneth-like features can be a significant component in invasive neoplasms and can occur at unusual sites such as the ampulla of Vater.
本文报告1例发生于十二指肠乳头绒毛状腺瘤性息肉的具有显著潘氏细胞分化的腺癌。含有明显嗜品红颗粒的潘氏样细胞是非腺性浸润性腺癌的主要成分，在相关的腺瘤性息肉中也可见到。溶菌酶、三色和过碘酸希夫消化染色以及电子显微镜检查证实这些颗粒本质上是溶酶体。该病例证实具有潘氏样特征的细胞可成为浸润性肿瘤的重要组成部分，并可发生于如十二指肠乳头等不寻常部位。
