Clonal nature of odontogenic tumours.
作者信息
Gomes Carolina Cavaliéri, Oliveira Carla da Silveira, Castro Wagner Henriques, de Lacerda Júlio César Tanos, Gomez Ricardo Santiago
机构信息
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
J Oral Pathol Med. 2009 Apr;38(4):397-400. doi: 10.1111/j.1600-0714.2008.00744.x. Epub 2009 Mar 2.
BACKGROUND
Although clonal origin is an essential step in the comprehension of neoplasias, there have been no studies to examine whether odontogenic tumours are derived from a single somatic progenitor cell. The purpose of this study was to investigate the clonal origin of odontogenic tumours.
METHODS
Fresh samples of seven ameloblastomas, two odontogenic mixomas, two adenomatoid odontogenic tumour, one calcifying odontogenic cyst, one calcifying epithelial odontogenic tumour (CEOT) and six odontogenic keratocyst (OKC) of female patients were included in this study. After DNA extraction, the HUMARA gene polymorphism assay was performed.
RESULTS
Most of the informative odontogenic lesions studied (12 out of 16) showed a monoclonal pattern. Among the polyclonal cases, two were OKC, one CEOT and one odontogenic mixoma.
CONCLUSIONS
Our results suggest that most odontogenic tumours are monoclonal.
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