Sedghizadeh Parish P, Wong Derek, Shuler Charles F, Linz Vincent, Kalmar John R, Allen Carl M
Division of Diagnostic Sciences, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90089-0641,
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Aug;104(2):e30-4. doi: 10.1016/j.tripleo.2006.06.050. Epub 2006 Oct 16.
The calcifying epithelial odontogenic tumor (CEOT), or Pindborg tumor, is a rare and benign odontogenic neoplasm that affects the jaw. The most common manifestation of CEOT is a unifocal or localized lesion of the involved jaw, which may appear clinically as a hard tissue swelling and radiographically as a mixed radiolucent-radiopaque mass. In this article, we present a unique case of CEOT affecting multiple sites in the maxilla and mandible of a 51-year-old white man. Though biopsy samples from all involved sites revealed similar histopathologic features consistent with CEOT, the fact that there was a multifocal presentation is an unusual phenomenon for CEOT and has never been reported. Multifocal odontogenic lesions are not typical but have been observed in conditions associated with known genetic mutations. For example, multiple odontogenic keratocysts are the most common feature of the inherited condition known as nevoid basal cell carcinoma syndrome. This case, however, is the first one to demonstrate that there may be a multifocal variant of CEOT that has not been previously recognized.
钙化上皮性牙源性肿瘤（CEOT），又称平博肿瘤，是一种罕见的良性牙源性肿瘤，可累及颌骨。CEOT最常见的表现是受累颌骨的单灶性或局限性病变，临床上可能表现为硬组织肿胀，影像学上表现为透射线与阻射线混合的肿块。在本文中，我们报告了一例51岁白人男性上颌骨和下颌骨多部位受累的CEOT罕见病例。尽管所有受累部位的活检样本均显示出与CEOT一致的相似组织病理学特征，但多灶性表现这一事实对于CEOT来说是一种不寻常的现象，且从未有过报道。多灶性牙源性病变并不典型，但在与已知基因突变相关的情况下曾有观察到。例如，多发性牙源性角化囊肿是遗传性疾病痣样基底细胞癌综合征最常见的特征。然而，该病例是首例证明可能存在此前未被认识的CEOT多灶性变体的病例。
