Maruya Jun, Narita Eriko, Nishimaki Keiichi, Heianna Joichi, Miyauchi Takaharu, Minakawa Takashi
Department of Neurosurgery, Akita Red Cross Hospital, 222-1 Nawashirosawa, Saruta, Kamikitate, Akita 010-1495, Japan.
J Clin Neurosci. 2009 Jun;16(6):832-4. doi: 10.1016/j.jocn.2008.08.024. Epub 2009 Mar 18.
A primary intracranial germinoma that involves the midbrain is rare. We describe an unusual case of primary cystic germinoma originating from the midbrain. A 29-year-old man presented with diplopia, and his MRI showed a cystic, ring-like enhanced lesion in the thalamo-mesencephalic junction. Open biopsy was performed and the diagnosis of germinoma was based upon the histopathological findings. Following chemotherapy and radiotherapy, the symptoms improved and the tumor disappeared. We propose that primary intracranial germinoma should be included in the differential diagnosis of midbrain tumors, because early diagnosis and appropriate treatment for midbrain germinoma improves clinical outcome.
原发性颅内生殖细胞瘤累及中脑的情况较为罕见。我们描述了一例起源于中脑的原发性囊性生殖细胞瘤的不寻常病例。一名29岁男性出现复视，其磁共振成像（MRI）显示丘脑 - 中脑交界处有一个囊性、环状强化病变。进行了开放性活检，根据组织病理学结果诊断为生殖细胞瘤。经过化疗和放疗后，症状改善，肿瘤消失。我们建议原发性颅内生殖细胞瘤应纳入中脑肿瘤的鉴别诊断，因为对中脑生殖细胞瘤的早期诊断和适当治疗可改善临床结局。
