Kreutz R
Institut für Klinische Pharmakologie und Toxikologie, Charité-Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, Berlin, Germany.
Internist (Berl). 2009 Apr;50(4):442-54. doi: 10.1007/s00108-008-2293-7.
The prevalence of arterial hypertension in Germany is 60-80% in individuals between 65 and 74 years of age. In older people there is also a positive correlation between blood pressure level and rise in mortality due to myocardial infarction and stroke. Antihypertensive therapy can considerably improve the prognosis of older hypertensive individuals. Treatment is of enormous importance in these patients, particularly for prevention of strokes, which will continue to increase in the future as a result of demographic trends. Older patients have an elevated risk of developing undesirable drug reactions while under therapy such as a drop in blood pressure in an erect/standing position. Taking into account individual risk factors for unwanted events and avoidance of drug interactions during polypharmacotherapy are important aspects in differential therapy with antihypertensive agents in the elderly.
在德国，65至74岁人群中动脉高血压的患病率为60%至80%。在老年人中，血压水平与心肌梗死和中风导致的死亡率上升之间也存在正相关。抗高血压治疗可显著改善老年高血压患者的预后。治疗对这些患者极为重要，尤其是预防中风，由于人口趋势，中风在未来将持续增加。老年患者在治疗期间发生不良药物反应的风险升高，如直立/站立位血压下降。在老年患者使用抗高血压药物进行个体化治疗时，考虑不良事件的个体风险因素以及避免多药联合治疗期间的药物相互作用是重要方面。
